3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical Center

描述（由申请人提供）：本提案要求支持骨质疏松性骨折研究（SOF）临床中心的研究者在我们竞争性更新和（部分）资助的5年研究的第4年和第5年期间分析数据、发表结果并继续科学参与SOF。我们不要求支持收集数据或分析样本，我们也没有改变资助的5年研究的任何方面。SOF于2006年8月更新，以研究为什么有些女性在第9和第10个十年的生活中实现了良好的下肢和认知功能，以及为什么有些女性在10年的随访中保持了下肢和认知功能的健康轨迹。我们正在专门测试肾功能、炎症和维生素D是否对维持和实现高水平的功能以及降低福尔斯和髋部骨折的风险很重要。每个SOF临床中心PI都带头制定了一个SOF目标。NIH资助了我们的20年考试，我们正在测量认知和下肢功能。我们的目标是在2008年9月底之前完成访视，以便我们可以开始选择和提取样本，并在第3年晚些时候开始生物标志物测定。大部分数据将在更新的第4年和第5年进行分析并产生论文。临床中心的研究人员--包括年轻的研究人员--将承担大部分工作。协调中心的经费已用了5年。然而，临床中心仅获得3年（2006年8月1日至2009年7月31日）的资助，以完成检查。临床中心3年的资助限制将无意中阻止临床中心研究者分析和发表他们开发的目标的结果。因此，我们请求支持SOF临床中心研究者在我们更新的第4年和第5年期间分析和发表本次资助的竞争性更新的结果，并继续参与SOF的科学活动。此外，NIA要求我们在本提案中纳入SOF公共数据共享计划。我们的计划建立在我们成功的公共访问门户网站SOF Online的基础上，并建议在网站上添加可下载和记录的公共发布数据集，以允许外部调查人员直接访问已确定的SOF数据。公共卫生相关性：骨质疏松性骨折研究（SOF）被竞争性地更新，以研究为什么一些女性在生命的第9和第10个十年中实现并保持高认知和身体功能，以及低福尔斯和骨折风险。SOF协调中心获得5年资助; SOF临床中心获得3年资助。为了实现这些目标，需要为SOF临床中心提供两年的支持。

DESCRIPTION (provided by applicant): This proposal requests support for the investigators in the Clinical Centers in the Study of Osteoporotic Fractures (SOF) to analyze data, publish results, and continue scientific participation in SOF during the 4th and 5th years of our competitively renewed and (partially) funded 5 year study. We are NOT requesting support for collecting data or assaying samples and we have NOT changed any aspect of the funded 5 year study. SOF was renewed in August 2006 to study why some women achieve excellent lower extremity and cognitive function in the 9th and 10th decades of life and why some women have maintained healthy trajectories of lower extremity and cognitive function over 10 years of follow-up. We are specifically testing whether renal function, inflammation, and vitamin D are important to maintaining and achieving high levels of function and lower risks of falls, and hip fractures. Each SOF Clinical Center PI took the lead in developing one of the SOF Aims. NIH funded our Year 20 Exam in which we are measuring cognitive and lower extremity function. We are on target to complete the visits by the end of September, 2008 so that we can begin to select and pull samples and start biomarker assays later in that 3rd year. The bulk of the data will be analyzed and papers produced in the 4th and 5th years of the renewal. Investigators at the Clinical Centers - including young investigators - would do most of that work. The Coordinating Center was funded for 5 years. However, Clinical Centers were funded for only 3 years (8/1/06-7/31/09) just to complete the Exam. The 3 year limit on Clinical Center funding would - inadvertently - prevent the Clinical Center investigators from analyzing and publishing results from the aims they developed. Therefore, we request support for the SOF Clinical Center investigators to analyze and publish results from this funded competitive renewal during the 4th and 5th years of our renewal and continue their essential participation in the scientific activities of SOF. In addition, NIA requested that we include a plan for public data sharing for SOF in this proposal. Our plan builds on our successful public access web portal, SOF Online, and proposes to add downloadable and documented public release data sets to the website to allow external investigators direct access to identified SOF data. PUBLIC HEALTH RELEVANCE: The Study of Osteoporotic Fractures (SOF) was competitively renewed to study why some women achieve and maintain high cognitive and physical function, and low risk of falls and fractures in the 9th and 10th decade of life. The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers.