The Impact of Sleep Deprivation on Affect Regulation in Young Adults

描述（由申请人提供）：项目概述：睡眠剥夺（SD）损害注意力，执行功能和情感调节。虽然研究不足，但了解睡眠和情绪调节之间的关系可能会揭示睡眠障碍导致精神疾病的重要途径。这与青春期和成年早期的抑郁发作特别相关，因为这些发育期与SD和情感性精神病理学风险增加有关。实验研究一致发现SD对健康个体自我报告的情绪有负面影响。下一步重要的是客观量化SD对情感反应和调节的影响，并使用更精确的客观和可量化的方法来检查情感障碍的个体间差异。候选人彼得·L。Franzen博士，研究了健康人群和患者群体在睡眠状态下的觉醒和信息处理。他寻求进一步的培训，以检查SD改变影响调节的途径，并最终解决SD在情绪障碍发展中的作用。在拟议的研究中，SD对情感反应/调节的心理生理和神经影像指标的影响将在年轻人中进行检查-这是情绪障碍发展的发育脆弱时期。它将导致R 01提案调查SD对处于抑郁症低和高家族风险的年轻人和成年人的情感调节的客观指标的影响。仔细检查SD在受控条件下对情感调节的影响，可能会揭示睡眠障碍相关的精神病理学特征脆弱性的预测因子，并且是开发睡眠在心理健康中作用的机械模型的第一步。在这些脆弱人群中识别与睡眠相关的风险因素不仅可以提出治疗性策略，还可以提出预防性策略，以减少睡眠不足的精神和神经行为后果。研究将在匹兹堡大学医学院精神病学系进行，该系是睡眠，情绪障碍和情感神经科学领域的世界研究中心。在这些领域具有专门知识的研究人员将担任导师和顾问。相关性：许多人在睡眠不足时会经历负面情绪影响。通过进一步了解睡眠不足如何导致情绪障碍，可以揭示睡眠与健康情绪功能之间的关系，并制定预防和干预策略，以减少情绪障碍的发生。这一点在青年时期尤其重要--这一时期的特点是睡眠不足，患情绪障碍的风险增加。

DESCRIPTION (provided by applicant): Project Summary: Sleep deprivation (SD) impairs attention, executive function, and affect regulation. Although understudied, understanding relationships between sleep and affect regulation may reveal important pathways by which sleep disturbances lead to psychiatric disorders. This is particularly relevant to the onset of depression during adolescence and early adulthood, as these developmental periods are associated with SD and increased risk for affective psychopathology. Experimental studies consistently find negative effects of SD on self-reported mood in healthy individuals. An important next step is to objectively quantify the impact of SD on affect reactivity and regulation, and to examine inter-individual variability in affective impairments using more precise objective and quantifiable methods. The candidate, Peter L. Franzen, Ph.D., has examined arousal and information processing during the sleep state in healthy and patient populations. He seeks further training to examine the pathways by which SD alters affect regulation and ultimately address the role of SD in the development of mood disorders. In the proposed research studies, the impact of SD on psychophysiological and neuroimaging indicators of affect reactivity/regulation will be examined in young adults - a developmentally vulnerable period for the development of mood disorders. It will lead to an R01 proposal investigating the impact of SD on objective indicators of affect regulation in young at adults at low and high familial risk for depression. Carefully examining the effects of SD on affect regulation under controlled conditions may reveal predictors of sleep disturbance-related trait vulnerability for psychopathology, and is a first step toward developing mechanistic models of the role of sleep in mental health. The identification of sleep-related risk factors in such vulnerable populations may suggest not only therapeutic but also preventative strategies to reduce the psychiatric and neurobehavioral consequences of sleep loss. Research will be conducted at the Department of Psychiatry, University of Pittsburgh School of Medicine, a world center for research in the areas of sleep, mood disorders, and affective neuroscience. Researchers with expertise in these areas will serve as mentors and consultants. Relevance: Many people experience negative mood effects when sleep deprived. By further understanding how sleep loss leads to emotional impairments, the relationship between sleep and healthy emotional functioning may be revealed, and prevention and intervention strategies to reduce the onset of mood disorders may be developed. This is particularly relevant in young adulthood - a time of life characterized by insufficient sleep and increased risk for the development of mood disorders.