Total Synthesis of the Litophynins, Ether-Bridged Cembranoid Natural Products of Marine Origin

拟议的研究方案涉及海洋天然产物石青素家族成员的全合成。石茶碱是桥接类膜类化合物中具有重要生物活性的一个亚类，以前未被合成。该研究方案将集中于发现新的途径来获得岩褐素，这些途径将足够有效和普遍，以适应许多与结构有关的生物活性海洋天然产品的构建。快速构建高功能化桥醚岩黄素核心的预期合成方法将结合Clark集团首创的金属类碳化合物和重排方法。然后将采用各种有效的环化策略来构建石茶碱的三环结构，随后的细化将用于制备该家族的单个成员。

The proposed research programme concerns the total synthesis of members of the litophynin family of marine natural products. The litophynins are a sub-class of the cladiellin family of bridged cembranoids that possess significant biological activities and have not been synthesised previously. The research programme will focus on the discovery of novel routes to the litophynins that will be sufficiently efficient and general to be adapted to the construction of many of the numerous structurally related bioactive marine natural products.The intended synthetic approach to the rapid construction of the highly functionalised bridged-ether core of the litophynins will incorporate metal carbenoid and rearrangement methodology pioneered by the Clark Group. A variety of efficient annulation strategies will then be employed to build the tricyclic structure of the litophynins, and subsequent elaboration will be used to prepare individual members of the family.