Identifying mechanisms of resistance to novel hormonal agents in patients with castrate-resistant prostate cancer

我是一名专注于前列腺癌的医学肿瘤学家，这种疾病每年导致3000多名澳大利亚男性死亡。最近的研究表明，新的激素治疗有助于晚期前列腺癌患者活得更长。不幸的是，虽然这些药物在最初开始时是有效的，但前列腺癌最终会对它们产生耐药性并再次开始生长。通过研究这些药物停止工作的原因，我希望为患有晚期前列腺癌的澳大利亚男性找到更好的治疗方法。

I am a medical oncologist focused on prostate cancer, a disease which kills over 3000 Australian men every year. Recent studies have shown that new hormone treatments help men with advanced prostate cancer live longer. Unfortunately, while these drugs are effective when first started, prostate cancers eventually become resistant to them and start growing again. By looking at why these drugs stop working, I hope to find better treatments for Australian men with advanced prostate cancer.