Chromosome Metabolism and Cancer Training Grant

此申请寻求对正在进行的染色体代谢和癌症的持续支持 培训研究人员探索染色体代谢和癌症之间的联系。 基因和基因组研究的进展极大地促进了对染色体的认识 代谢（基因表达，染色质组装，分离，端粒和着丝粒，DNA修复， 等等）。并阐明了其在癌症发生和发展中的重要性。25名培训教师是专家， 弗雷德哈钦森癌症研究中心人类生物学基础科学部 中心许多人都是各自领域的顶尖科学家，他们共同组成了一个有凝聚力的团队， 从不同但互补的角度处理问题。他们还包括结构生物学家 分子和细胞生物学家，并利用各种模式生物，如线虫，苍蝇和酵母， 除了脊椎动物和培养细胞在他们的研究。该计划的广度和深度应该有助于 培养优秀的年轻科学家，用创造性的方法来理解癌症机制。 两个博士前职位要求保持目前的支持水平，这一成功的 该计划是在分子和细胞生物学（MCB）成立后十年前启动的 研究生课程。博士后职位也将保持在目前的5个水平。 博士预科生将在MCB学生中招募，他们通过以下方式进入博士课程 竞争激烈，在全国名列前茅。博士后研究生是从一个 与CMTP学院合作的优秀研究员。博士前学生被任命为培训 在他们选择了一个永久的实验室，完成了实验室轮换和他们的一部分， 必修课程博士后培训由独立研究组成，辅以严谨的 在培训补助金教师面前的季度报告和组织CMTP赞助的经验 研讨会等此外，所有受训人员都将受益于该中心研究人员可参加的丰富活动， 包括强大的跨学科项目，使基础科学家接触临床和公共卫生 癌症的方面。希望该计划将培养出对以下问题有深入了解的年轻科学家： 染色体代谢，并致力于探索其与癌症的原因，治疗和预防的各种联系。

This application seeks continuing support for the on-going Chromosome Metabolism and Cancer Training Program that trains researchers exploring the links between chromosome metabolism andcancer. Advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism (gene expression, chromatin assembly, segregation, telomeres and centromeres, DNA repair, etc.) and illustrated its importance in cancer initiation and progression. The 25 training faculty are experts in this area from the Basic Sciences Human Biology Divisions of the Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly and yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists with creative approaches to understanding cancer mechanisms. Two predoctoral positions are requested to maintain the current level of support of this successful program that was initiated ten years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will also be maintained at the current level of five. Predoctoral trainees will be recruited among the MCB students, who enter the PhD program through vigorous competition and are among the best in the nation. Postdoctoral trainees are drawn from an outstanding pool of fellows working with CMTP Faculty. Predoctoral students are appointed to the training grant after they have chosen a permanent laboratory and completed lab rotations and a portion of their required coursework. Postdoctoral training consists of independent research, supplemented by rigorous quarterly presentations in front of training grant faculty and experience in organizing CMTP-sponsored seminars. In addition, all trainees will benefit from the rich activities available for researchers at this Center, including the strong interdisciplinary programs that expose basic scientists to clinical and public health aspects of cancer. It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention.