Cellular and Molecular Mechanisms of Immune Inflammatory Reactions

描述(由申请者提供)：这笔培训补助金现已进入第25个年头，为约翰霍普金斯大学医学院独特的免疫学跨学科博士前和博士后培训计划提供支持。培训补助金是免疫学研究生项目的核心资金来源。这个跨部门项目的使命是为学生和研究员提供免疫反应生物学的细胞、生化和遗传学方法方面的培训。我们试图为学员提供识别免疫学中重要研究问题的能力，找到这些问题的解决方案，对生物学问题进行广泛和创造性的思考，并有效地与他人交流想法。有34名教职员工参加了该项目，为学生和研究员提供了广泛的培训机会。这些领域包括免疫发育的遗传和细胞方面、T细胞抗原识别、免疫调节、耐受性、结构生物免疫蛋白、补体、先天免疫、自身免疫、免疫细胞信号、癌症免疫学、IgE介导的免疫反应和宿主对感染的反应。在这些领域，基础科学和/或临床医学相关领域的机构力量加强了培训环境。基础研究和临床疾病研究之间的相互促进是培训环境的一个重要方面。除了免疫学之外，博士前课程还强调基础生物化学和分子和细胞生物学方面的严格培训。在整个博士前培训计划的教学和研究部分，通过多种机制密切监测受训者的进展情况。博士后研究员可以选择专注于基础免疫学或免疫学疾病的实验室。实施了一项广泛和成功的招收少数民族学生的方案。

DESCRIPTION (provided by applicant): This Training Grant, now entering its 25th year, provides support for a unique interdisciplinary pre-doctoral and post-doctoral training program in Immunology at the Johns Hopkins University School of Medicine. The Training Grant is the core source of funding for the Graduate Program in Immunology. The mission of this Interdepartmental program is to provide students and fellows with training in cellular, biochemical, and genetic approaches to the biology of the immune response. We seek to provide trainees with the ability to identify significant research questions in immunology, to find solutions to these questions, to think broadly and creatively about biological problems, and to communicate ideas effectively to others. There are 34 faculty members who participate in the program and provide a broad range of training opportunities for students and fellows. These areas include genetic and cellular Aspects of immune development, T cell antigen recognition, immune regulation, tolerance, structural biology immune proteins, complement, innate immunity, autoimmunity, immune cell signaling, cancer immunology, IgE-mediated immunologic reactions and the host response to infection. In these areas, the training environment is enhanced by institutional strength in relevant areas of basic science and/or clinical medicine. Cross-fertilization between basic research and clinical disease studies is an important aspect of the training environment. The predoctoral program places emphasis on rigorous training in basic biochemistry and molecular and cellular biology in addition to immunology. Progress of trainees throughout the didactic and research portions of the pre-doctoral training program is monitored closely through multiple mechanisms. Post-doctoral fellows have the option of selecting laboratories that focus on basic immunology or immunologic diseases. An extensive and successful program for recruiting minority students has been implemented.