Pathogenesis of Infectious Diseases Training Program

描述（由申请人提供）：该计划的目标是培养生物医学研究人员，重点是医生科学家，在基础和转化生物医学研究，重点是传染病的发病机制。培训计划将利用威尔康奈尔医学院，洛克菲勒大学和亚伦钻石艾滋病研究中心的资源。该计划的教师是资助的科学家，致力于研究和培训。六名新的潜在导师被纳入其中，他们都得到了独立的NIH研究支持。培训教师在通过NIH Fogarty计划进行国际生物医学科学家的研究和培训方面有着悠久的成功合作历史，他们已将这些经验应用于美国医生科学家的培训。教师们都认为，医生科学家是真正的濒危物种，并致力于通过与博士后学员建立长期的指导关系来解决这个问题。研究培训的广泛领域是：病毒学，免疫学和与全球重要性传染病相关的转化研究。学员有机会参加K30临床研究硕士课程，或根据情况参加独立的研究生水平免疫学和分子生物学课程。在目前的供资期间（1999-2008年），任命了23名受训人员，17人完成了培训。其中10人获得了NIH“K”奖，1人获得了研究补助金，2人获得了准备中的“K”赠款。获得资助的学科领域包括KSHV-HHV 8、HIV发病机制、HIV基因型耐药性、HCV-HIV合并感染、HIV-TB合并感染、多药耐药细菌、HIV疫苗开发、利什曼原虫发病机制和M.结核病-NO相互作用两名前受训人员已获得国家卫生研究院“R”奖，两名在主要公共卫生职位（疾病预防控制中心，纽约）。有4名少数族裔受训人员（3名非洲裔美国人，1名西班牙裔）和9名女性受训人员。该计划将继续招募已经完成临床培训（医学，儿科）并正在寻求学术调查职业的医生。该培训补助金将为医生提供从临床培训过渡到实验室的机会。研究培训将持续2-3年。 相关性（参见说明）：该培训计划将为医生科学家提供所需的技能和指导，以便在美国和全球范围内成功开展对公共卫生重要性的传染病研究。具体而言，培训将侧重于结核病、疟疾、艾滋病、丙型肝炎病毒和潜在的生物恐怖主义因素。

DESCRIPTION (provided by applicant): The objective of this program is to train biomedical researchers, with an emphasis on physician-scientists, in basic and translational biomedical research focusing on the pathogenesis of infectious diseases. The training program will utilize the resources of Weill Cornell Medical College, the Rockefeller University, and the Aaron Diamond AIDS Research Center. The program's faculty are funded scientists, committed to research and training. Six new potential mentors have been included, all with independent NIH research support. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs, and they have applied that experience to the training of US physician-scientists. The faculty members share the view that the physician-scientist is truly an endangered species and are committed to address this issue by establishing long-term mentoring relationships with postdoctoral trainees. The broad areas of research training are: virology, immunology, and translational research related to infectious diseases of global importance. Trainees have the opportunity to enroll in the K30 Masters in Clinical Investigation program or take independent graduate level immunology and molecular biology courses as appropriate. During the current funding period (1999-2008), 23 trainees have been appointed and 17 have completed training. Ten have received NIH "K" awards, one a research supplement, and two have "K" grants in preparation. The subject areas for the funded awards are KSHV-HHV8, HIV pathogenesis, HIV genotypic resistance, HCV-HIV coinfection, HIV-TB coinfection, multidrug resistance bacteria,-HIV vaccine development, leishmania pathogenesis and M. tuberculosis-NO interaction. Two former trainees have already received NIH "R" awards and two are in major public health positions (CDC, NYC). There have been four minority trainees (3 African-American, 1 Hispanic) and nine female trainees. The program will continue to recruit physicians who have completed their clinical training (medicine, pediatrics) and are seeking academic investigative careers. This training grant will provide physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years. RELEVANCE (See instructions): This training program will provide physician-scientists with the skills and mentoring needed to embark on successful careers conducting research in infectious diseases of public health importance both in the United States and worldwide. Specifically, the training will focus on tuberculosis, malaria, AIDS, hepatitis C virus, and potential agents of bioterrorism.