Research Training in Rehabilitation for Brain Injury and Neurological Disability

描述（由申请人提供）：这是第一次重新提交申请，申请国家机构研究服务奖的续期，以表彰一项成功的博士后培训计划，重点是脑损伤和神经残疾的医疗康复研究。项目研究员建议每年培训4名博士后水平的受训人员，每人为期2-3年。该培训计划的基础是在约翰霍普金斯物理医学和康复部（PM&R）和肯尼迪克里格研究所在巴尔的摩。肯尼迪克里格研究所是约翰霍普金斯大学医学院儿童和年轻人神经残疾临床护理和研究的主要中心。这些项目补充了PM&R部门的临床和研究项目，该部门为约翰霍普金斯医院、巴尔的摩的好撒玛利亚医院和约翰霍普金斯湾景医疗中心的成年人提供服务。学员有机会与肯尼迪克里格研究所，PM&R系，约翰霍普金斯彭博公共卫生学院，神经病学，神经科学，生物医学工程和机械工程系的教师顾问合作。该计划的目标是：1）培训临床医生和基础科学家，他们将继续做出重要贡献，促进脑和脊髓损伤及其他神经系统残疾患者的康复，2）使这些受训人员具备成为独立研究人员所需的技能。培训计划的重点是在一个指导期的假设驱动的临床和/或实验室为基础的研究。教师在六个主要康复主题中的一个或多个方面具有专业知识：1）脑行为关系和儿科创伤性脑损伤的康复; 2）从重症监护到康复的连续护理; 3）吞咽和吞咽困难恢复的生理学; 4）大脑可塑性和功能恢复; 5）脊髓康复和再生;和6）流行病学和康复结果。培训计划管理委员会为受训人员实现核心研究能力的进展提供具体目标，并密切监测进展情况。该计划提供了每周会议，期刊俱乐部和教学讲座，反映了约翰霍普金斯的研究和学术环境的强大课程。该计划已经产生了30多名研究人员和大学教职员工谁是积极的康复研究，和几个谁拥有高知名度的职业生涯，并持有两个R 01赠款。在过去三年中完成该计划的六名毕业生目前获得NIH职业发展奖的支持。 该培训计划直接关系到改善数百万患有创伤性脑损伤、脊髓损伤、中风、多发性硬化症、自闭症、帕金森病和许多相关疾病的儿童和成人的治疗和减少残疾。

DESCRIPTION (provided by applicant): This is the first resubmission of an application for renewal of an Institutional National Research Service Award for a successful postdoctoral training program in medical rehabilitation research that focuses on brain injury and neurological disability. The PIs propose to train 4 postdoctoral level trainees per year, each for a total duration of 2-3 years. The training program is based in the Johns Hopkins Department of Physical Medicine and Rehabilitation (PM&R) and in the Kennedy Krieger Institute in Baltimore. The Kennedy Krieger Institute is a major center for clinical care and research on neurological disabilities in children and young adults on the Johns Hopkins University medical campus. These programs complement the clinical and research programs of the Department of PM&R that serve adults at the Johns Hopkins Hospital, the Good Samaritan Hospital in Baltimore and the Johns Hopkins Bayview Medical Center. Trainees have the opportunity to work with faculty advisors from the Kennedy Krieger Institute, the Department of PM&R, the Johns Hopkins Bloomberg School of Public Health, and the Departments of Neurology, Neuroscience, Biomedical Engineering and Mechanical Engineering. The goals of the program are to: 1) train clinicians and basic scientists who will go on to make important contributions that advance the rehabilitation of patients with brain and spinal cord injuries and other neurological disabilities, and 2) equip these trainees with the skills needed to become independent grant-funded investigators. The focus of the training program is on a mentored period of hypothesis-driven clinical and/or laboratory based research. Faculty have expertise in one or more of six major rehabilitation themes: 1) brain-behavior relationships and rehabilitation for pediatric traumatic brain injury; 2) the continuum of care from intensive care to rehabilitation; 3) physiology of swallowing and recovery from dysphagia; 4) brain plasticity and recovery of function; 5) spinal cord rehabilitation and regeneration; and 6) epidemiology and rehabilitation outcomes. A training program management committee provides specific goals for progress of trainees to achieve core research competencies, and it monitors progress closely. The program provides a strong curriculum of weekly conferences, journal clubs and didactic lectures that reflect the research and scholarly environment at Johns Hopkins. The program has produced more than 30 researchers and university faculty members who are active in rehabilitation research, and several who have high profile careers and hold two R01 grants. Six graduates who completed the program in the last three years are currently supported by NIH career development awards. This training program is directly related to improving treatment and reducing disability for millions of children and adults with disorders including traumatic brain injury, spinal cord injury, stroke, multiple sclerosis, autism, Parkinson's disease and numerous related disorders.