High Throughput Genetic Analysis of Bladder Cancer

描述（由申请人提供）：约翰霍普金斯医疗机构和加州大学伯克利分校的研究人员提出了一个项目，题为“膀胱癌和尿液沉积物的高通量遗传分析”。本提案的目标是提高我们对驱动膀胱癌进展的分子遗传变化的理解，因为我们开发和整合了用于检测这些遗传改变的新型高通量方法。这些方法将用于将我们的发现转化为临床环境，我们将评估遗传改变作为疾病结果的预测因子和分子检测的目标。与传统的孤立调查方法不同，该计划强调受试者，组织样本，资源，技术专长和数据分析策略的共享。我们的项目不仅将为基础研究工作提供临床指导，而且将促进最先进的高通量技术直接转化为基础实验室和临床领域。

DESCRIPTION (provided by applicant): A program project is proposed by researchers at the Johns Hopkins Medical Institutions and the University of California at Berkeley entitled, "High Throughput Genetic Analysis of Bladder Cancer and Urine Sediment." The goals of this proposal are to improve our understanding of the molecular genetic changes that drive bladder cancer progression as we develop and integrate novel high throughput approaches for the detection of these genetic alterations. These approaches will be used to translate our findings into the clinical setting where we will evaluate genetic alterations as predictors of disease outcome and targets for molecular detection. Unlike traditional methods of isolated investigators, this program emphasizes sharing of subjects, tissue samples, resources, technical expertise and data analysis strategies. Our program will not only offer clinical direction for basic research efforts, but will also facilitate the direct translation of state of the art high throughput technology into the basic laboratory and clinical arena.