Clefts/Craniofacial Anomalies and Cancer Susceptibility

简介（由申请人提供）：候选人：Renato Menezes博士是一名牙科医生，目前正在匹兹堡大学口腔医学院口腔生物学系进行博士后培训。他之前的研究重点是研究与人类颌骨骨质流失相关的基因和与唇裂相关的基因。他的短期目标是获得颅面和牙齿遗传疾病的基础知识，特别强调了解唇裂的病因学，流行病学和表型。另一个短期目标是获得统计遗传学方面的专业知识。对口唇裂和统计遗传学的深入了解对他独立研究生涯所需能力的发展至关重要。他的长期目标是成为一名独立的、跨学科的研究科学家，拥有一个资助的研究项目，该项目将汇集遗传学、分子生物学和统计学方面的专业知识，以推进我们对颅面和牙齿遗传疾病等复杂特征的理解。环境：颅面和牙科遗传学中心正在进行nidcr资助的颅面和牙科疾病研究。匹兹堡大学长期以来一直为博士后和研究助理提供卓越的研究和职业发展培训。导师和顾问：Alexandre Vieira博士和Mary Marazita博士将担任本奖项的导师。维埃拉博士是一项资助项目的私家侦探负责对与牙齿异常有关的唇裂进行基因分析。他在颅面和牙齿遗传疾病方面有专长。Mary Marazita博士是统计遗传学和口腔研究方面的专家，是颅面和牙科遗传学几项资助的首席研究员。癌症流行病学专家Emanuela Taioli博士将担任顾问。研究生涯发展计划：除了与导师在其专业领域进行的一系列教程外，PI还将参加相关的讲习班，研讨会和社会会议。候选人的进步将由他的导师和外部委员会进行评估。他的进步也将通过他的设计，执行和撰写他的研究领域的论文的能力来评估。主要目标是能够在该奖助金的最后一年申请R01奖助金。研究研究：该项目的目的是确定可能导致颅面/牙齿异常和癌症的基因，并有助于更好地理解复杂的颅面和牙齿遗传疾病。

DESCRIPTION (provided by applicant): Candidate: Dr. Renato Menezes is a dentist currently undergoing postdoctoral training at the University of Pittsburgh, School of Dental Medicine, Department of Oral Biology. His prior research focuses on investigation of genes related to bone loss in the human jaws and genes associated with oral clefts. His short-term goal is to gain fundamental knowledge of craniofacial and dental genetic disorders, with special emphasis on understanding the etiology, epidemiology and phenotypes of oral clefts. Another short-term goal is to gain expertise in statistical genetics. A deeper understanding of oral clefts and statistical genetics is critical to the development of abilities necessary for his independent research career. His long term goal is to become an independent, interdisciplinary research scientist with a funded research program that will bring together expertise in genetics, molecular biology and statistics to advance our understanding of complex traits like craniofacial and dental genetic disorders. Environment: The Center for Craniofacial and Dental Genetics has ongoing NIDCR-funded grants examining craniofacial and dental disorders. The University of Pittsburgh has a long standing track record of providing postdoctoral fellows and research associates with exceptional research and career development training. Mentors & Consultants: Dr. Alexandre Vieira and Dr. Mary Marazita will serve as mentors for this award. Dr. Vieira is the PI on a grant for the genetic analysis of oral clefts in association with dental abnormalities. He has expertise in craniofacial and dental genetic disorders. Dr. Mary Marazita, an expert in statistical genetics and orafacial research is the PI on several craniofacial and dental genetics grants. Dr. Emanuela Taioli an expert in cancer epidemiology will serve as a consultant. Research Career Development Plan: In addition to a series of tutorials conducted with the mentors in their areas of expertise, the PI will also participate in relevant workshops, seminars, and society meetings. The progress of the candidate will be evaluated by his mentors and an external committee. His progress will also be evaluated through his ability to desing, execute and write his papers about his research area. The major goal is to be able to apply for a R01 grant during the last year of this award. Research Study: The aim of this project is to identify genes that can contribute to both craniofacial/dental anomalies and cancer, and contribute to the better understanding of complex craniofacial and dental genetic disorders.