Identifying the relationship between biochemical markers and healing in chronic leg ulcers treated with compression

慢性腿部溃疡是60岁以上人群中1-3%的人疼痛、行动不便和生活质量下降的重要原因。这种疾病很难治愈，通常会成为一个长期问题，给澳大利亚的医疗保健系统造成了超过5亿美元的年成本。社区的额外成本包括失去行动能力有限的人所需的生产力和社会支持系统。随着65岁以上人口的数量预计在未来几十年内翻一番，这个问题将变得越来越严重。大多数慢性腿部溃疡是由静脉疾病引起的，而压迫绷带疗法是公认的标准治疗方法。然而，关于压迫治疗相关的细胞反应以及它们如何促进伤口愈合的信息很少。这里提出的项目将检查细胞对压迫的反应，并调查这些细胞反应与伤口愈合之间的关系。从这项研究中获得的知识将为改进促进伤口愈合的技术、提高溃疡愈合率、做出关于伤口护理治疗的明智决定、提高生活质量和降低医疗成本提供宝贵的信息。

Chronic leg ulcers are a significant cause of pain, immobility and decreased quality of life for 1 - 3% of the over 60 years age group. The condition is difficult to heal and commonly becomes a long term problem, costing the Australian health care system over $500 million - year. Additional costs to the community include loss of productivity and social support systems necessary for people with limited mobility. As the number of people aged over 65 years is expected to double in the next few decades, this problem will become increasingly significant. Most chronic leg ulcers are caused by venous disease, and compression bandage therapy is the accepted standard treatment. However, there is little information available on the cellular responses associated with compression treatment and how they promote wound healing. The project proposed here will examine the cellular responses to compression and investigate the relationships between these cellular responses and wound healing. Knowledge gained from the study will provide valuable information for improved techniques to promote wound healing, improved ulcer healing rates, informed decisions on wound care treatment, improved qualtiy of life and reduced health care costs.