Epigenetic regulation of AEC Plasticity and epithelial-mesenchymal transition

描述（由申请人提供）：本提案的目的是招募一名新的独立研究者（NIl）担任肺重症监护医学科（DPCCM）的终身职位。NIl将被纳入南加州大学肺部生物学中心（USC-CLB）的协作环境，该中心是DPCCM的基础科学研究组成部分。USC-CLB的目标是通过促进研究和促进核心研究人员之间的支持性环境中的相互作用来促进对肺部疾病致病机制的理解，这些核心研究人员专注于肺泡上皮细胞和分子生物学。USC-CLB的一个关键目标是吸引肺细胞生物学的年轻研究人员，并支持他们向独立过渡。为了促进这些目标，USC-CLB提供了可供USC-CLB研究人员使用的共享设备，并运营细胞培养核心，为研究人员提供研究试剂。USC-CLB促进与其他学科和部门的研究人员的合作，他们有兴趣将其专业知识应用于肺生物学。应聘者必须在肺细胞和分子生物学方面有很强的背景和培训。基于与USC-CLB核心研究主题的相关性，NIl将重点研究肺泡上皮细胞分化和上皮-间充质转化的表观遗传调控，这将促进USC-CLB与表观基因组中心之间的互动，并为USC-CLB带来新的专业知识。NIl将可以访问USC-CLB中的所有共享设备以及USC健康科学园区的所有核心。NIL将由PI和由USC-CLB成员组成的委员会以及合作研究者指导，他们将通过定期评估生产力密切监测NIL的进展。NIl将与所有USC-CLB研究人员和其他部门，中心和研究所的特定相关专业知识的合作者进行互动。DPCCM内的USC-CLB将为NIl成功建立独立的研究事业提供协作和智力支持的环境。该机构承诺在本P30提案所要求的供资期限之外再提供两年的支持。 由新独立研究者进行的研究将提供新的见解，以了解肺气隙细胞在损伤后启动修复的机制。这一领域的进展与许多急性和慢性肺部疾病有关，从这些研究中获得的见解的应用应导致肺损伤和疾病结局的改善。

DESCRIPTION (provided by applicant): The objective of this proposal is to recruit a newly independent investigator (NIl) to a tenure track position in the Division of Pulmonary Critical Care Medicine (DPCCM). The NIl will be incorporated into the collaborative environment of the USC Center for Lung Biology (USC-CLB), the basic science research component of DPCCM. Goals of the USC-CLB are to advance understanding of pathogenic mechanisms of pulmonary disease by facilitating research and promoting interactions in a supportive environment among a core group of investigators focused on cell and molecular biology of lung alveolar epithelium. A key objective of the USC-CLB is to attract young investigators in lung cell biology and to support their transition to independence. To promote these goals, the USC-CLB provides shared equipment that is available for use by USC-CLB investigators and operates a Cell Culture Core to provide investigators with research reagents. The USC-CLB fosters collaborations with investigators in other disciplines and departments who have an interest in applying their expertise to lung biology. The individual to be hired will have strong background and training in lung cell and molecular biology. Based on relevance to the core research themes of the USC-CLB, the NIl will focus his/her research on epigenetic regulation of alveolar epithelial cell differentiation and epithelial-mesenchymal transition, which will facilitate interactions between the USC-CLB and the Epigenome Center and bring new expertise to the USC-CLB. The NIl will have access to all shared equipment in the USC-CLB and to all cores on the USC Health Sciences Campus. The NIl will be mentored by the PI and a committee comprised of USC-CLB members as well as collaborating investigators who will closely monitor progress of the Nil through regular assessments of productivity. The NIl will interact with all USC-CLB investigators and collaborators with specific relevant expertise in other departments, centers and institutes. The USC-CLB within DPCCM will provide a collaborative and intellectually supportive environment for the NIl to successfully establish an independent research career. The institution is committed to providing two additional years of support beyond the period of funding requested in this P30 proposal. Studies to be performed by the newly independent investigator will provide novel insights into mechanisms by which cells lining the air spaces of the lung initiate repair following injury. Advances in this area are relevant to a number of acute and chronic lung diseases and application of insights gained from these studies should lead to improvements in outcome in lung injury and disease.