Stanford Mood Disorders Center: Enhancing Core Clinical Research Resources

描述（由申请人提供）：这是一份回应RFA-Recovery Act有限竞争的申请：通过生物医学研究支持新教员招聘以增加研究资源（P30） ~为招募一名初级教员临床科学家提供支持，以从事并进一步发展情绪障碍生物标志物领域的多学科项目。我们目前正在寻找一名助理教授来研究一生中情绪障碍的功能性脑成像生物标志物。该教员将在斯坦福大学医学院精神病学和行为科学系任职，并将成为斯坦福大学情绪障碍中心的一员。该提案的具体目标是：1。为一名助理教授、临床科学家提供启动资金，主要研究情绪障碍，特别强调功能性磁共振成像（f-MRI）研究，旨在阐明这些障碍的神经生物学。2. 提供丰富的跨学科环境，以支持初级教员的持续研究职业发展。3. 为抑郁症和/或焦虑症患者和对照组的f-MRI跨学科试点研究提供资金。最近的研究表明，重度抑郁症或广泛性焦虑症患者的情绪处理和调节存在潜在差异，并在这些疾病患者的非共病和共病队列中测试这些生物标志物，这就是所提出的跨学科研究的一个例子。在这组核心实验中确定的焦虑和抑郁相关的生物标志物将随后应用于青少年和老年人的试点研究。综上所述，这些研究可能有助于我们理解抑郁症在整个生命周期中的病理生理学。

DESCRIPTION (provided by applicant): This is an application in response to RFA-Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research (P30) ~ to provide support for recruitment of a junior faculty clinician scientist to work in and further develop a multidisciplinary program in the area of biomarkers of mood disorders. We are currently searching for an assistant professor to work on functional brain imaging biomarkers of mood disorders across the lifespan. The faculty member will have a primary appointment in the Department of Psychiatry and Behavioral Sciences at Stanford University Medical School and will be a member of the Stanford University Mood Disorders Center. The specific aims of the proposal are: 1. To provide start up funding for an assistant professor, clinician scientist with a primary interest in mood disorders with a particular emphasis on functional magnetic resonance imaging (f-MRI) studies aimed at elucidating the neurobiology of these disorders. 2. To provide an enriched interdisciplinary environment to support the continued research career development of junior faculty member(s). 3. To provide funding for interdisciplinary pilot studies on f-MRI of depressed and/or anxious patients and controls across the lifespan. An example of the type of indisciplinary research proposed is reflected in recent work pointing to potential differences in the processing and regulation of emotion in patients with major depression or generalized anxiety disorder, and to test these biomarkers on noncomorbid and comorbid cohorts of patients with these disorders. Anxiety- and depression-related biomarkers identified in this core set of experiments will then be applied in adolescent and geriatric pilot studies. Taken together, these studies may help our understanding of the pathophysiology of depression across the life span. PUBLIC HEALTH RELEVANCE: Mood disorders are extremely common and are associated with great morbidity. Interdisciplinary research involving brain imaging can help understand the biological bases of major depression and aid in differential diagnosis and treatment development. A junior faculty will be supported to conduct research that can help our understanding of the development of depression across the lifespan.