Molecular Physiology Core Applied to Acute Lung Injury

描述（由申请人提供）：本P30申请旨在提供资源，招募Eric施密特博士领导肺科学和重症监护医学部的分子生理学和成像核心（MPIC）。该部门总部设在科罗拉多州丹佛大学，包括大学的附属学院（在国家犹太健康，丹佛健康和医院系统，丹佛VA医院）。研究专长包括急性肺损伤（ALI）、肺动脉高压、肺癌、COPD、职业医学、间质性肺病和哮喘等。该部门是NIH资助的CO临床和转化科学，CO大学综合癌症中心和心血管肺研究（CVP）实验室计划项目资助的重要参与者。该部门是每个NHLBI肺部部门临床网络的成员，包括ARDSnet，COPDnet，IPFnet和哮喘临床研究网络（ACRN）。该部门已收集了大量的机构资源，以实施转化肺研究计划，该计划将支持MPIC。MPIC将以ALI为重点，以其多变的表现形式构建。这种强调是基于ALI的整体相关性和发病机制的广度，最终是几种肺部疾病过程的一部分。MPIC的专业知识还将扩展到肺动脉高压、间质性肺病和吸烟引起的肺损伤的研究。选择聘用施密特博士来建立这一核心是基于一个有选择的招聘、专业发展、职业支持和长期保留计划的过程。在主要研究者Mark Geraci博士、Ivor道格拉斯博士和Rubin Tuder博士的直接支持下，施密特博士将协调医学院（医学、麻醉学和儿科）、科罗拉多CTSI内的附属项目和部门之间的互动，以及涉及CVP和医学系成像核心的项目计划。一个研究委员会，其中将包括几个既定的国家卫生研究院资助的调查人员在肺部疾病，将协助博士施密特与核心的管理。评估核心、科学生产力和施密特博士的职业发展和指导的计划已经到位。 该提案针对急性肺损伤的综合生理和成像研究，每年涉及190，000例患者。所提出的MPIC提供了一个中心实验元素，用于成功转换临床数据和相关模型系统，因为它与一系列其他方法学协同作用，这些方法学单独无法解决肺部疾病（包括急性肺损伤）的复杂性。

DESCRIPTION (provided by applicant): This P30 application seeks to provide resources to recruit Dr. Eric Schmidt to lead the Molecular Physiology and Imaging Core (MPIC) in the Division of Pulmonary Sciences and Critical Care Medicine. The Division is based at the University of CO Denver and encompasses the University's affiliate faculty (at National Jewish Health, Denver Health and Hospital System, and the Denver VA Hospital). The research expertise encompasses acute lung injury (ALI), pulmonary hypertension, lung cancer, COPD, occupational medicine, interstitial lung diseases and asthma, among others. The Division is an integral participant of the NIH-funded CO Clinical and Translational Sciences, University of CO Comprehensive Cancer Center, and Program Project Grant in the Cardiovascular Pulmonary Research (CVP) Lab. The Division has membership in every NHLBI Lung Division Clinical Network, including the ARDSnet, COPDnet, IPFnet, and the Asthma Clinical Research Network (ACRN). The Division has gathered substantial institutional resources to implement the Program in Translational Lung Research, which will support the MPIC. The MPIC will be built with a focus on ALI, in its protean manifestations. This emphasis is based on the overall relevance of ALI and the breadth of pathogenetic mechanisms, which ultimately are part of several lung disease processes. The expertise of the MPIC will also extend to studies in pulmonary hypertension, interstitial lung disease, and cigarette smoke induced lung injury. The choice to recruit Dr. Schmidt to establish this Core was based on a selective process of recruitment, professional development, career support, and long-term retention plans. With the direct support of the PI, Dr. Mark Geraci, and Drs. Ivor Douglas and Rubin Tuder, Dr. Schmidt will coordinate the interaction across affiliated programs & the Division & Departments within the medical school (Medicine, Anesthesiology and Pediatrics), the Colorado CTSI, and programmatic initiatives involving the CVP, and the imaging core at the Department of Medicine. A research committee, which will include several established NIH-funded investigators in lung diseases, will assist Dr. Schmidt with the administration of the Core. A plan to assess the Core, scientific productivity, and Dr. Schmidt's career development & mentorship are in place. This proposal targets the integrated physiological and imaging study of acute lung injury, which compromises 190,000 patients per year. The proposed MPIC provides a central experimental element for the successful translation from/to clinical data and relevant model systems, as it synergizes with a range of other methodologies, which in isolation cannot address the complexity of pulmonary diseases, including acute lung injury.