New Faculty in Sleep Medicine

描述（由申请人提供）：这份NHLBI PSO申请要求为一名新的独立研究者提供两年的工资和适当的启动资金，该研究者的研究将补充布里格姆妇女医院（BWH）睡眠医学研究中心的研究。该研究中心的使命是开拓睡眠医学的发现之路，并培养下一代学术睡眠医学的领导者。该部门有31名教师，20名博士后和50多名辅助人员，大部分精力花在研究上。这些研究活动由每年约1180万美元的研究补助金资助。该部门有许多相互作用的研究项目和核心，涵盖睡眠和昼夜生理学的大多数方面，以及睡眠病理生理学（睡眠障碍的机制和治疗）。然而，我们已经确定了一个重要的研究领域，目前在我们的中心还没有得到很好的研究，即昼夜节律系统与疾病的相互作用。特别是，我们对昼夜节律系统在导致易感患者群体早晨不良心血管事件（中风、心肌梗死和心源性猝死）急剧增加中的作用的理解存在重大差距。我们已经确定了一位引人注目的新独立研究者，他的研究已经朝着这个方向发展，他将被提升为医学助理教授。如果获得P03奖，该机构承诺为该个人提供适当的研究设施，包括使用临床研究中心的BWH强化生理监测单元，该中心是哈佛催化-临床和转化科学中心的一个组成部分。此外，研究者将充分利用BWH教师发展和多样性中心的许多职业发展资源。在该部门研究中心资深教师的密切研究和职业指导下，我们预计PSO奖将导致有关昼夜节律系统在不良心血管事件的昼夜模式中的作用的重要发现，并极大地促进学术睡眠医学中最有前途的未来领导者之一的职业发展。

DESCRIPTION (provided by applicant): This NHLBI PSO application requests funding for two years salary plus appropriate start up funds for a newly independent investigator whose research will complement the research underway in the Brigham & Women's Hospital's (BWH) Division of Sleep Medicine's research center. The research center's mission is to forge a path of discovery in sleep medicine and to train the next generation of leaders in academic sleep medicine. The Division has 31 faculty, 20 postdoctoral fellows and over 50 support staff, with the majority of effort spent on research. These research activities are funded by annual research grants of ~$11.8 million. The Division has a number of interacting research programs and cores, covering most aspects of sleep and circadian physiology, as well as sleep pathophysiology (mechanisms and therapy for the sleep disorders). However, we have identified an important area of research that is not currently well studied in our center, namely the interaction of the circadian system with disease. In particular, there is a critical gap in our understanding of the role of the circadian timing system in causing the very robust morning increase in adverse cardiovascular events (strokes, myocardial infarction, and sudden cardiac death) in vulnerable patient groups. We have identified a spectacular newly independent investigator whose research has moved in this direction and who is poised for promotion to Assistant Professor of Medicine. Should this P03 award be made, the institution is committed to providing appropriate research facilities for this individual, including use of the BWH Intensive Physiological Monitoring Unit in the Center for Clinical Investigation, a component of the Harvard Catalyst-Clinical and Translation Science Center. In addition, the investigator will fully utilize the many career development resources in the BWH Center for Faculty Development and Diversity. Together with close research and career mentorship from senior faculty in the Division's research center, we anticipate that a PSO award will lead to important discoveries concerning the role of the circadian system in the day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine. A PSO award will lead to important discoveries concerning the role of the circadian system in the very robust day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine.