THE NINDS MASS SPECTROMETRY PROTEOMICS CENTER FOR NEUROSCIENCES AT MSSM

神经科学中的一个主要科学挑战是在分子水平上鉴定和表征 各种生理状况和病理性神经障碍中的细胞变化。的关键 这一奋进的成功是开发和实施新的工具，快速和敏感的蛋白质 鉴定和表征其翻译后修饰。质量灵敏度高 光谱测定法已成为进行此类研究的宝贵工具。拟议的“NINDS质量”的主要目标是 MSSM神经科学光谱蛋白质组学中心”是建立一个核心设施， 支持NINDS资助的神经科学研究项目的人员，以扩大和升级 我们的质谱设备的能力和灵敏度，应用最先进的质谱 神经科学和神经疾病中涉及的关键蛋白质和神经肽分析技术 研究，并使和加强在西迈山学校的神经科学研究计划， 药 该核心设施的具体目标是：（1）提供快速，成本效益高，质量好的质量 为NINDS和西奈山其他神经科学研究人员提供光谱蛋白质组学服务 和其他NINDS资助的研究人员在其他研究所，以进行尖端研究，其中 新的质谱技术用于解决重要的生物化学和生物医学问题。（二） 将新开发的质谱技术从研究实验室转移到NINDS核心 设施和扩大能力，提高质谱技术的灵敏度， NINDS资助和其他神经科学导向的研究人员。(3)为了教育NINDS资助的调查人员， 其他神经科学方向的科学家，以及他们的工作人员在使用质谱法进行蛋白质分析， 神经科学(4)刺激新的研究计划并促进神经科学的合作

A major scientific ctiallenge in neuroscience is the identification and characterization at molecular level of the cellular changes in various physiological conditions and pathalogical neurological disorders. Critical to the success of this endeavor is the development and implementation of new tools for rapid and sensitive protein identification and characterization of their post-translational modifications. High sensitivity of mass spectrometry has become an invaluable tool for such studies. The major goal of the proposed "NINDS Mass Spectrometry Proteomics Center for Neuroscience at MSSM" is to establish a core facility with dedicated personnel in supporting NINDS-funded neuroscience research programs, to expand and upgrade the capacity and sensitivity of our mass spectrometry facility, to apply state-of-the-art mass spectrometry technologies to critical protein and neuropeptide analysis involved in neuroscience and neurological disease researches, and to enable and strengthen neuroscience research program at Mount Simai School of Medicine. The specific aims of this core facility are: (1) To provide rapid, cost-effective, and high-quality mass spectrometry proteomics services for NINDS and other neuroscience-oriented investigators at Mount Sinai and other NINDS-funded investigators In other institute in order to perform cutting-edge researches in which new mass spectrometric technologies are used to solve important biochemical and biomedical problems. (2) To transfer newly developed mass spectrometry technologies from research laboratory to the NINDS core facility and expand the capacity and upgrade the sensitivity of mass spectrometry techniques for assisting NINDS-funded and other neuroscience-oriented investigators. (3) To educate NINDS-funded investigators, other neuroscience-oriented scientists, and their staffs on using mass spectrometry for protein analysis in neuroscience. (4) To stimulate new research initiatives and facilitate collaborations in neuroscience