Pilot Projects Component

该试点项目的目的是把新的调查人员进入酒精领域 研究-通过提供资金（a）年轻的研究人员和（B）建立研究谁提出 项目脱离了他们正在进行的研究。该计划的资金将足以获得试点 这些数据可用于支持独立研究补助金的申请，或为未来的研究奠定基础。 重新申请DEARC资金。争取试点资金的过程包括内部招标 一个严格的审查程序，依靠内部和外部审查， 最高品质。该过程在管理核心中进行了描述。 我们已拨出八个试点项目名额， 的资金。目前的申请列出了四个潜在的试点项目，这些项目已经通过了我们的 内部和外部审查程序。其他项目一直开放，以允许活力和 酒精研究领域的流动性（尽管描述中包括了两个潜在的项目）。 最初的三项研究如下。(1)罗素马修斯（助理教授，部神经科学和 Phyiology，Upstate）是细胞外基质在发育神经系统中作用的专家。他 建议检查产前暴露于乙醇对塑料事件的影响， 躯体感觉皮层的桶。(2)John Lombardo（教授，部科特兰）研究 多氯联苯的毒性。他将探讨的问题之一是围产期的影响， 多氯联苯暴露增加乙醇摄入量对两性异形的影响。(3)Sandra Mooney（助理教授，部 神经科学和生理学，上州）正在研究胎儿编程。她建议， 在原肠胚形成或神经元发生的关键时刻，乙醇可以导致社会行为的长期变化， 青少年。(4)迈克尔Nishnikov（讲师，宾厄姆顿大学，宾厄姆顿）将探讨的作用， κ阿片受体（a）作为围产期乙醇暴露的介质，（B）在乙醇中作为 有食欲/令人厌恶的物质。每个拟议的试点项目都至少与一个主要项目相结合 项目，并使用至少两个科学核心。 总之，试点项目将作为酒精研究的种子在中央新 约克。这将鼓励新的研究人员和新的想法，以探索乙醇毒性在发展神经 系统.

The PILOT PROJECT PROGRAM is designed to bring new investigators into the field of alcohol research-by providing funds (a) to young investigators and (b) to established investigators who propose projects departing from their ongoing research. Funding from this program will be sufficient to obtain pilot data that can be used to support applications for independent research grants or can seed future reapplications for DEARC funding. The process for competing for pilot funding includes internal solicitation of proposals and a rigorous review process relying on internal and external reviews to select studies of the highest quality. This process is described in the ADMINISTRATIVE CORE. We have allotted eight slots for Pilot Projects, two projects will commence in each of the first four years of the DEARC funding. The current application lists four potential pilot projects that have passed through our internal and external review processes. The other projects have been left open to allow for the vibrancy and fluidity of the field of alcohol research (though two potential projects have been included in the description). The initial three studies are as follows. (1) Russell Matthews (Asst. Prof., Dept. of Neuroscience and Phyiology, Upstate) is an expert in the role of extracellular matrix in the developing nervous system. He proposes to examine the effects of prenatal exposure to ethanol on plastic events in the development of barrels in somatosensory cortex. (2) John Lombardo (Prof., Dept. of Psychology, SUNY- Cortland) studies the toxicity of polychlorinated biphenyls. Among the issues that he will explore is the effect of perinatal exposure to PCBs to increase ethanol intake on sexual dimorphisms. (3) Sandra Mooney (Asst. Prof., Dept. of Neuroscience and Physiology, Upstate) is investigating fetal programming. She proposes that exposure to ethanol at a key time, gastrulation or neuronogenesis, can lead to long-term changes in social behavior in adolescents. (4) Michael Nishnikov (Instructor, Binghamton University, Binghamton) will explore the role of kappa opioid receptors (a) as mediators of perinatal ethanol exposure and (b) in ethanol acting as an appetitive/aversive substance. Each of the proposed Pilot Projects integrates with at least one MAIN PROJECT and uses at least two of the scientific CORES. In summary, the PILOT PROJECT PROGRAM will serve as the seed for alcohol research in Central New York. It will encourage new researchers and new ideas to explore ethanol toxicity in developing nervous systems.