ALOPECIA AREATA REGISTRY AND IMMUNOGENETIC MECHANISMS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该登记处的目的是：1)确定大量斑秃或更严重的脱发(全面性脱发和泛发性脱发)的受试者。 2)选择一组特征明确的受试者，以获得详细的临床数据、皮肤科医生检查、实验室研究、头皮数码照片、血清样本、白细胞和DNA。来自美国的具有斑秃、AT或AU特征的个体患者、同胞配对和多个家庭将被录入。这些数据将被放置在一个关系数据库中，样本将被储存起来，以供未来的研究使用。 3)提供数据和样本来验证AA是一个多基因TRAIL的假设，并要求多个基因的交互作用以充分表达(AU/AT)加上一个环境触发因素。 4)进行关联性研究，比较不同表型再障患者包括人类白细胞抗原等位基因频率的差异。 5)对有多个受累个体的同胞对和多个家系进行AA遗传标记的检测。只有国家登记处才能提供收集大量患者材料所需的资源类型。 GCRC将通过提供临床服务来满足大量参与者的需求，最大限度地减少参与注册的参与者的成本，并简化诊所的数据收集工作，从而帮助这一项目。数据仍将在德克萨斯州休斯顿的中心站点进行处理和分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Registry is: 1) To identify large numbers of subjects who have alopecia areata or more severe forms (alopecia totalis and universalis). 2) To select specific groups of well-characterized subjects for detailed clinical data, dermatoligist's exam, lab studies, digital photos of the scalp, sera samples, white blood cells, and DNA. Individual patients, sib-pairs, and multiplex families from the United States with well-characterized alopecia areata, AT or AU will be entered. Thte data will be placed in a relational database and the samples will be banked for future research studies. 3) To provide data and samples to test the hypothesis that AA is a multigenic trail and request the interaction of several genes for full expression (AU/AT) plus an environmental trigger factor. 4) To conduct association studies that compare differences in precent frequency of alleles of genes including HLA in the different phenotypes of AA. 5) To examine the inheritance markers with AA in sib-pairs and multiplex families with multiple affected individuals. Only a natinoal registry can provide the type of resources needed to collect this large number of patient material. The GCRC will aid this project by providing clinical availability to accomodate the large number of participants, minimize the cost to participants involved in the registry, and streamline the data collection in clinic. The data will still be processed and analyzed at the central site in Houston, TX.