CLINICAL IMPLICATIONS OF GASTRIC BYPASS SURGERY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Roux-en-Y胃旁路术是最常见的肥胖手术类型。 它会导致胃容量严重受限和吸收不良。 它与更大的体重减轻有关，但与限制性手术（例如胃束带）相比，并发症的风险也更大。 可能的不良后果包括蛋白质缺乏、液体分布的异常变化和瘦肉组织的过度损失。 目前还不清楚为什么这种手术在某些人身上成功减肥，而对其他人却没有产生最小的负面影响。 有必要确定与积极结果相关的因素，以改善临床管理。这项研究将探讨胃旁路手术后饮食摄入、身体成分变化、静息能量代谢和营养状况之间的关系。其中一个主要假设是，手术后前5至6周内的蛋白质消耗量越大，手术后6个月和1年的结果越积极。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Roux-en-Y gastric bypass is the most common type of obesity surgery. It induces both severe restriction of stomach capacity, and malabsorption. It is associated with greater weight loss, but also greater risk for complications than restrictive procedures (e.g. gastric banding). Possible adverse outcomes include protein deficiency, abnormal shifts in fluid distribution, and excessive loss of lean tissue. It is unclear why this surgery yields successful weight loss with minimal negative effects in some individuals, but not others. There is a need to identify factors associated with positive outcomes, in order to improve clinical management. The proposed study will investigate the relationships between dietary intake, changes in body composition, resting energy metabolism, and nutritional status after gastric bypass surgery. One of the primary hpotheses is that greater protein consumption in the first five to six weeks after surgery will be associated with more positive outcomes at 6 months and 1 year after surgery.