MEXICAN AMERICAN ADMIXTURE MAPPING DEVELOPMENT AND APPLICATION TO NIDDM (NON-

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 墨西哥裔美国人混合物图谱的开发及其在非胰岛素依赖型糖尿病中的应用 混合物图谱是一种正在发展的检查复杂遗传疾病的方法，它补充了连锁分析和关联方法。 对于任何疾病，如果亲本群体中的易感基因分布不同，则可以使用最近混合的群体来定义关键染色体区域。这是基于确定混合群体中染色体片段的祖先的能力。 这项研究旨在提供改进的工具，阐明糖尿病肾病和2型糖尿病的遗传基础，使用分子遗传学策略称为混合物定位。 这利用了这样一个事实，即已知某些种群在历史上的某个时刻是不同遗传祖先的混合体。 在这种情况下，要研究的人群是墨西哥裔美国人群体，他们代表了美洲印第安人和欧洲遗传背景的混合体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mexican American Admixture Mapping Development and Application to NIDDM (Non-Insulin Dependent Diabetes) Admixture mapping is a developing method for examining complex genetic diseases that complements linkage analysis and association methods. For any disease, a recently admixed population can be used to define critical chromosomal regions if there is a different distribution of susceptibility genes in parental populations contributing to the admixed population. This is predicated on the ability to define the ancestry of the chromosomal segments in the admixed population. This study is designed to provide improved tools to elucidate the genetic basis for diabetic nephropathy and Type 2 diabetes using a molecular genetics strategy known as admixture mapping. This uses the fact that certain populations are known to be a mixture of different genetic ancestry at some point in history. In this case, the population to be studied is the Mexican American group who represent an admixture of Amerindian and European genetic backgrounds.