ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE (ADNI): PROTOCOL ADNI-024, DATED

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 阿尔茨海默病S病神经成像倡议研究是一项多中心生物标志物试验，旨在确定在预防和治疗AD的2期和3期临床试验中最有希望作为替代终点的疾病进展生物标志物。这是一项非随机自然史非治疗研究，将在美国和加拿大的大约50个地点招募800名受试者，其中包括200名正常对照、400名轻度认知障碍患者和200名轻度阿尔茨海默病(AD)患者，进行纵向随访。MCI患者和对照组将被跟踪3年，AD患者将被跟踪2年。在UCI，我们将招募48名受试者(24名MCI，12名轻度AD，12名正常)。 总体目标是收集当前和未来分析所需的数据，并进行有限的一系列分析。所有临床数据将由加州大学圣地亚哥分校(UCSD)协调中心收集、监测和存储。宾夕法尼亚大学将收集生物标记物样本。所有原始和处理的图像数据将在神经成像实验室(LONI)存档。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Alzheimer s Disease Neuroimaging Initiative (ADNI) study is a multi-center biomarker trial to identify biomarkers of disease progression that are most promising as surrogate endpoints in phase 2 and 3 clinical trials for the prevention and treatment of AD. This is a non-randomized natural history non-treatment study in which a total of 800 subjects including 200 normal controls, 400 individuals with Mild Cognitive Impairment (MCI), and 200 subjects with mild Alzheimer s Disease (AD) will be recruited at approximately 50 sites in the United States and Canada for longitudinal follow up. Subjects with MCI and controls will be followed for 3 years, those with AD for 2 years. At UCI we will enroll 48 subjects (24 MCI, 12 Mild AD, and 12 normals). The overall objectives are to collect the required data for current and future analyses and to carry out a limited set of analyses. All clinical data will be collected, monitored, and stored by the Coordinating Center at University of California, San Diego (UCSD). University of Pennsylvania (U Penn) will collect biomarker samples. All raw and processed image data will be archived at the Laboratory of Neuroimaging (LONI).