LEUKOCYTE ADHESION IN ALLERGIC INFLAMMATION/SEROTONIN (5-HT) AND 5-HT2A IN ALLER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究表明，嗜酸性粒细胞滚动，粘附和从血管迁移到过敏性炎症的各个部位，包括肺，并表明粘附分子，细胞因子以及趋化因子可能在导致循环嗜酸性粒细胞隔离的炎症级联反应中发挥关键作用。本研究的目的是进一步了解这些介质在嗜酸性粒细胞介导的过敏性炎症中的作用和重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have revealed that eosinophils roll, adhere and transmigrate from blood vessels to various sites of allergic inflammation, including the lungs, and suggest that adhesion molecules, cytokines as well as chemokines may play a critical role in the inflammatory cascade leading to sequestration of circulating eosinophils. The purpose of this study is to further understand the role and importance of these mediators in eosinophil-mediated allergic inflammation.