LUPRON DEPOT IN THE TREATMENT OF CENTRAL PRECOCIOUS PUBERTY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 以往的研究表明，醋酸亮丙瑞林(路普隆)在治疗性早熟方面是有效的。在20世纪90年代末，S、李博士和HMC的研究对象参与了其中一些临床试验。这项拟议的研究旨在确定使用路普隆治疗中枢性性早熟儿童的长期效果。约50人将在全国范围内参与这项研究，约9名之前在HMC学习过的受试者预计将参与这项后续研究。每个受试者将被要求在GCRC进行一到两次办公室访问，届时将完成以下评估：身高测量、体重测量、完成一份询问生殖健康的简短问卷，以及为女性参与者进行腹部超声波检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have indicated that leuprolide acetate (Lupron Depot) is efficacious in the treatment of precocious puberty. In the late 1990's Dr. Lee and research subjects at HMC participated in some of these clinical trials. The purpose the proposed research study is to determine the long-term effects of using Lupron in children with central precocious puberty. Approximately 50 people will take part in this research nationwide and about 9 subjects who were previously studied at HMC are expected to take part at this follow up study. Each subject will be asked to have one or two office visits in the GCRC, at which time the following assessments will be completed: height Measurement, weight Measurement, completion of a brief questionnaire that will ask about reproductive health, and an abdominal Ultrasound for female participants.