CARDIOVASCULAR MRI IN CHILDHOOD CANCER SURVIVORS (PILOT STUDY)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 接受治疗的儿童恶性肿瘤的长期存活者经历心血管事件的发生率增加，包括急性冠状动脉和血管内综合征以及充血性心力衰竭（CHF）。癌症治疗（化疗和放疗）的这些不利的长期并发症对原本相对健康的20至40岁个体的功能能力、发病率和死亡率产生不利影响。目前，尚不存在识别无症状癌症幸存者发生心血管事件风险增加的标志物。此外，对癌症治疗可能影响心血管事件发生的机制的理解是不可用的。 MRI标记物在老年人中是精确的，并且预测心血管事件，而不依赖于临床状况的存在，例如高血压、糖尿病和高胆固醇血症，这些也已知与不良结果相关。因此，我们建议将心脏MRI应用于儿童癌症幸存者心血管健康的机构试点研究。我们的首要目标是评估cMRI在描述儿童癌症幸存者不良心血管结局的预测因子中的效用。为了完成这些提交，我们需要确定获取儿童癌症幸存者预后MRI信息的可行性，并定义年轻成年人群中这些MRI测量值的方差，以确定未来研究的样本量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Long term survivors of treated childhood malignancies experience an increased incidence of cardiovascular events including acute coronary and cerebro-vascular syndromes, and congestive heart failure (CHF). These untoward, long-term complications of cancer treatment (chemotherapy and radiation therapy) adversely impact the functional capacity, morbidity, and mortality of otherwise relatively healthy 20 to 40 year-old individuals. At present, markers to identify asymptomatic cancer survivors at increased risk of developing cardiovascular events do not exist. Moreover, understanding of the mechanisms by which cancer treatment could influence the occurrence of cardiovascular events is unavailable. MRI markers are precise in older adults, and forecast cardiovascular events independent of the presence of clinical conditions, such as hypertension, diabetes, and hypercholesterolemia that are also known to be associated with adverse outcomes. We therefore propose to apply cardiac MRI in an institutional pilot study of cardiovascular health in childhood cancer survivors. Our overarching goal is to evaluate the utility of cMRI in delineating predictors of adverse cardiovascular outcomes in childhood cancer survivors at risk. To accomplish these submissions, we need to determine the feasibility of acquiring prognostic MRI information in survivors of childhood cancer, and define the variance of these MRI measures in a young adult population for determining sample sizes in future studies.