GENE TARGETS FOR INTRAVENTRICULAR HEMORRHAGE (IVH)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在研究为什么一些早产儿会出现脑室内出血，而有些则没有。IVH是脑内出血，最常见的是早产儿。希望这项研究将有助于确定是否存在与婴儿IVH有关的遗传标记。 在怀孕32周前出生的婴儿中，大约有20%会发生脑室出血[比预产期提前2个月]。医生已经证明，虽然一些病情严重、出生体重极低的婴儿会出现IVH，但其他[同样患病的早产儿]则不会。为什么IVH可能发生在一些婴儿身上，而不是其他婴儿身上，我们还不完全理解。有信息表明，寻找特定的遗传标记可以识别出脑出血的高危成年人。这项研究的目的是了解患有IVH的婴儿是否可能具有在没有IVH的婴儿中没有的特定遗传标记。遗传标记可以用来帮助确定某人是否有患某些疾病或疾病的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is looking at why some premature infants have intraventricular hemorrhage [IVH] and some do not. IVH is bleeding inside the brain and occurs most commonly in children born prematurely. It is hoped that this research will help to identify whether there is a genetic marker linked to babies with IVH. Intraventricular hemorrhage occurs in approximately 20% of babies born before 32 weeks of pregnancy [2 months before their due date]. Doctors have shown that while some very ill, very low birth weight infants have IVH, others [equally sick preterm infants] do not. Why IVH may occur in some babies and not others, we do not fully understand. There is information available suggesting that looking for specific genetic markers can identify adults who are at high risk for brain bleeds. The purpose of this study is to see if babies with IVH may have specific genetic markers that are not found in babies who do not have an IVH. Genetic markers may be used to help determine whether someone is at risk for developing certain diseases or conditions.