MULTI-CENTER TRIAL TO EVALUATE HOME-BASED ASSESSMENT METHODS FOR ALZHEIMER DISEA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对于用于进行预防阿尔茨海默病的临床试验的有效、高效和经济的方法存在未满足的需求。传统的亲自到诊所就诊既耗时又昂贵，并且可能将某些人排除在参与之外，例如年龄较大或移动的较少或患有严重疾病的人。这些人可能是认知能力下降风险最大的人，以及那些没有经济来源前往研究地点的人。 预防性试验也需要长时间的观察，这些同样的健康、资源和运输问题可能导致显著的脱落。这些障碍增加了临床试验的费用，因为它们需要大的样本量、昂贵的临床工作人员和长的观察期。因此，基于家庭的评估可能会导致更有代表性的招聘那些最有可能下降，更好地保留和减少研究费用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an unmet need for effective, efficient and economical methods for conducting clinical trials to prevent Alzheimer s disease. Traditional in-person visits to a clinic are time consuming and costly and may exclude certain individuals from participation, such as those who are older, or are less mobile or who have significant medical illnesses. These may be the very people who are at greatest risk for cognitive decline, as well as those without financial resources for transportation to a study site. Prevention trials also require long observation periods and these same issues of health, resources, and transportation may cause significant drop out. These obstacles increase expense of clinical trials as they require large sample sizes, costly clinical staff and long observation periods. Thus, home-based assessments may lead to more representative recruitment of those most at risk for decline, better retention and reduced study costs.