REFUEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体目的是测试12个月增加食物摄入量的有效性，以改善月经紊乱女性的骨骼健康和恢复月经周期，这些女性经常锻炼并表现出慢性能量缺乏。我们将确定以下内容：1)增加卡路里摄入量干预，导致女性运动性月经紊乱(EAMD)和骨密度(BMD)低至正常的能量过剩和体重增加是否逆转了食物限制和能量负平衡对骨结果的有害影响；2)雌激素依赖和雌激素非依赖性途径对骨结果的相对贡献；3)雌激素状态或骨吸收或形成标志物的任何改善效果是否转化为可检测到的改善骨结果的变化，如系列双能X射线吸收测量仪(DXA)和pQCT测量所评估的那样，这可能影响骨折风险；4)体重、体脂和瘦质量的变化对BMD和月经恢复的相对贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of this study is to test the effectiveness of 12 months of increased food intake to improve bone health and restore menstrual cycles in women with menstrual disturbances who exercise regularly and exhibit chronic energy deficiency. We will determine the following: 1) if an increased caloric intake intervention that results in an energy surplus and weight gain in women with Exerciseassociated menstrual disturbances (EAMD) and low to normal bone mineral density (BMD) reverses the deleterious effects of food restriction and negative energy balance on bone outcomes; 2) the relative contributions of estrogen-dependent and estrogen-independent pathways to bone outcomes; 3) if any improved effects of estrogen status or markers of bone resorption or formation translate into detectable changes in improved bone outcomes, as assessed by serial dual energy x-ray absorptiometry (DXA) and pQCT measurements, that may impact fracture risk; and 4) the relative contribution of changes in body weight, body fat and lean mass to BMD and resumption of menses.