EFFECT OF VITAMIN D3 ON THE IFNA SIGNATURE IN PATIENTS WITH LUPUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项多中心、双盲、安慰剂对照试验将调查补充维生素D对系统性红斑狼疮(SLE)患者干扰素信号的影响。具有干扰素特征的维生素D缺乏的系统性红斑狼疮患者将被随机分配到每天接受0、2000或4000国际单位的胆钙化醇(维生素D3)治疗12周。将对潜在的临床效果和安全性进行评估和监测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This multi-center double-blind placebo controlled trial will investigate the effect of vitamin D supplementation on the interferon signature in patients with systemic lupus erythmematosus (SLE). Vitamin D deficient patients with SLE who possess the interferon signature will be randomized to receive 0, 2000 or 4000 IU/daily of cholecalciferol (vitamin D3) for 12 weeks. Potential clinical effects as well as safety will be assessed and monitored.