CLINICAL TRIAL: EFFECT OF CHRONIC MACROLIDE ADMINISTRATION ON COPD EXACERBATIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将招募中到重度COPD患者，他们要么在过去一年内COPD恶化，要么使用补充氧气。符合条件的受试者将被随机接受大环内酯类抗生素、阿奇霉素或安慰剂，为期一年。主要结果将是确定每天服用阿奇霉素是否会降低COPD恶化的频率或严重程度。我们将每月通过电话或门诊对受试者进行跟踪，在他们接受分配的学习治疗期间，以及在他们停止学习治疗一个月后进行诊所访问。我们还将在某些诊所就诊和一个月的后续诊所就诊时采集血液，以确定慢性大环内酯类药物治疗对特定血液产品的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will recruit patients with moderate to severe COPD who have either had a COPD exacerbation within the past year or who use supplemental oxygen. Eligible subjects will be randomized to receive either a macrolide antibiotic, azithromycin, or placebo for one year. The primary outcome will be to determine whether or not taking azithromycin daily will decrease the frequency or severity of COPD exacerbations. We will follow subjects monthly, either by phone or by clinic visit, while they receive their assigned study treatment and at a clinic visit one month after they stop the study treatment. We will also collect blood at certain clinic visits and the one-month follow-up clinic visit to determine the effect of chronic macrolide treatment on specific blood products.