CLINICAL TRIAL: PACTG 1058:INTENSIVE PHARMACOKINETIC STUDIES OF ANTIRETROVIRAL D

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 治疗艾滋病毒感染需要至少3种药物的组合，通常还需要更多的药物。几种用于治疗艾滋病毒的药物会影响人体清除其他艾滋病毒药物的方式。其中许多相互作用已经在成人中进行了研究，但对它们在儿童和青少年中的应用知之甚少。这项研究将观察儿童和青少年在12小时内服用三种感兴趣的艾滋病毒药物组合之一的艾滋病毒药物的水平。这些信息将帮助医生决定他们应该开多少药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Treating HIV infection requires combinations of at least 3, and often many more drugs. Several of the drugs used to treat HIV affect how the body eliminates other HIV drugs. Many of these interactions have been studied in adults, but far less is known about their use in children and adolescents. This study will look at the level of HIV drugs over a 12-hour period in children and adolescents who have been prescribed one of three combinations of HIV drugs of interest. This information will help doctors decide how much drug they should prescribe.