MACCHESS PROGRAM FOR NEW STATION FOR LONG WAVELENGTH CRYSTALLOGRAPHY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该计划的主要重点是将CHESS F3弯磁站升级为灵活的双聚焦高强度X射线束线，用于长波长蛋白质晶体学，包括SAD和微晶研究。新功能的关键将是一个灵活的光学系统，可以容纳用户可选择的窄能量带通合成多层反射镜和聚焦元件，以优化特定的数据收集要求。长波长、低能量的X射线能力在今天的同步辐射源中并不常见，因为大多数光束线已经被设计成提供高通量。最好的高通量X射线源利用插入装置、摆动器或波动器作为其X射线源。插入装置确实产生高X射线强度，但它们同时也产生高热负荷。为了处理这些热负荷，束线设计有真空窗和石墨过滤器，以消散热量并保护储存环超高真空环境。然而，窗口吸收长波长光，并且使得几乎不可能在低于8 keV（1.（5分）。 我们的合作者对利用长波长的强大光束线表现出极大的兴趣。 1)Cingolani小组（纽约州立大学北部医科大学）研究了

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary focus of this initiative is to upgrade the CHESS F3 bend-magnet station to be a flexible, double-focused, high-intensity X-ray beamline for long wavelength protein crystallography, including SAD and microcrystal studies. Key to the new capabilities will be a flexible optics system that can accommodate a user-selectable choice of narrow energy-bandpass synthetic multilayer mirrors and focusing elements to optimize particular data collection requirements. Long wavelength, lower energy X-ray capabilities are not commonly available at synchrotron radiation sources today because most beamlines have been designed to deliver high flux. The best high-flux X-ray sources utilize insertion devices, wigglers or undulators, as their X-ray sources. Insertion devices do produce high X-ray intensities but they also produce high heat loads at the same time. To handle these heat loads, beamlines are designed with vacuum windows and graphite filters to dissipate the heat and protect storage ring ultra-high vacuum environments. The windows, however, absorb the long wavelength light and make it virtually impossible to collect high-flux, high signal-to-noise data at wavelengths below 8 keV (1. 5 ¿). Our collaborators have shown tremendous interest in utilizing a powerful beamline at long wavelengths. 1) The Cingolani group (SUNY Upstate Medical University) deals with the mechanisms of