FULLERENE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 富勒烯的水溶性衍生物具有独特的医药应用潜力，因为富勒烯笼子保护包裹的金属离子免受外界的化学攻击和体内金属离子的释放。衍生的水溶性Gd基金属富勒烯是一种优秀的磁共振造影剂，对于没有直接Gd-OH2键的试剂来说，具有非常大的质子弛豫度。幻影和活体核磁共振研究都显示出有希望的结果 1)研究了离子强度对这些水溶性富勒烯聚集性质的影响。 2)研究生理条件下人血清白蛋白(HSA)和小鼠血清对富勒烯聚集特性的影响。 3)跟踪伽多富勒烯在细胞培养中的聚集行为，检查其在细胞内的聚集情况，从而探索伽多富勒烯作为第一种细胞内MRI造影剂的潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Water-soluble derivatives of endohedral metallofullerenes possess unique potential for medicinal applications since the fullerene cage protects the encapsulated metal ion from external chemical attack and metal ion release in the body. Derivatized water-soluble Gd-based metallofullerenes are excellent MRI contrast agents with unusually large proton relaxivities for agents with no direct Gd-OH2 bonding. Phantom and in vivo MRI studies have both shown promising results 1) Study the affect of ionic strength on the aggregation properties of these water-soluble gadofulllerenes. 2) Study the effect of Human Serum Albumin (HSA) and mice serum on the aggregation properties of the gadofullerenes under physiological conditions. 3) Follow the aggregation behaviour of the gadofullerenes in cell cultures and check for the accumulation inside cells, thereby exploring the potential of gadofullerenes as the first intracellular MRI contrast agents.