STYLOPEPTIDE 2, PROLINE-RICH CYCLODECAPEPTIDE FROM SPONGE STYLOTELLA SP

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 从海洋来源分离的非核糖体衍生的环肽的数量继续增长。 这样的肽对于酶促降解相对稳定，并且由于极性较小，因此比线性类型更具有生物学可利用性。 富含脯氨酸的环肽构成了一个相对较新的类别。 这一组的大多数成员是海绵衍生的七肽或八肽，其中非极性氨基酸残基（通常具有一个或两个芳香族代表）散布在脯氨酸单元之间。 实例包括axinellins、axinastatins、hymenamides、phakellistatin、stylisins、stylissamides、stylopeptide wainunuamide和dominicin。 Phakellistatin 7-9和12是富含脯氨酸的环状十肽的实例。 我们现在已经报道了一种新的脯氨酸型十肽，stylopeptide 2的分离和表征，其从提供stylopeptide 17和stylostatin 1.11的海绵Stylotella sp.的同一收集物中获得

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of non-ribosomal derived cyclic peptides isolated from marine sources continues to grow. Such peptides are relatively stable toward enzymatic degradation and, in being less polar, are more biologically available than the linear type. Proline-rich cyclopeptides constitute a relatively new class. Most members of this group are sponge-derived hepta- or octapeptides with non-polar amino acid residues (usually with one or two aromatic representatives) interspersed among the proline units. Examples include the axinellins, axinastatins, hymenamides, phakellistatins, stylisins, stylissamides, stylopeptide wainunuamide, and dominicin. Phakellistatins 7-9 and 12 are examples of proline-rich cyclic decapeptides. We have now reported the isolation and characterization of a new proline-type decapeptide, stylopeptide 2, obtained from the same collection of the marine sponge Stylotella sp. that provided stylopeptide 17 and stylostatin 1.11