3D SAP-EPI FOR USE IN T1- & SUSCEPTIBILITY-WEIGHTED IMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 用于几种需要快速成像的对比度机制的标准回波平面成像(EPI)的主要优点是其“快照”功能，允许用户在几个方向(扩散加权成像[DWI])、时间帧和/或平均重新对准单独的EPI图像。然而，单次激发(Ss)-EPI中存在的失真仍然是这项技术在临床上推进的唯一最引人注目的不利因素。EPI中沿相位编码方向的每像素极低的带宽也会导致非共振伪影(例如，水-脂肪漂移、磁化率伪影、涡流失真和B0漂移伪影)和T2*引起的模糊。为了加快k空间的遍历速度，人们提出了交错EPI算法，但其对运动相关伪影的敏感性是众所周知的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major benefit of standard echo-planar imaging (EPI) used for several contrast mechanisms requiring fast imaging is its 'snapshot' capability, which allows one to realign separate EPI images over several directions (diffusion-weighted imaging [DWI]), temporal frames, and/or averages. However, the distortions present in single-shot (ss)-EPI have remained the single most compelling detriment to the advance of this technique in the clinics. The extremely low bandwidth per pixel along the phase-encoding direction in EPI also leads to the development of off-resonance artifacts (e.g. water-fat shift, susceptibility artifacts, eddy current distortions, and B0 shift artifacts) and T2* induced blurring. To speed up k-space traversal, interleaved EPI has been proposed but its sensitivity to motion-related artifacts is well known.