GLUTAMATERGIC PATHWAYS IN CHILDREN WITH AND AT RISK FOR DEVELOPING MANIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：我们的目的是比较双相后代和健康对照者的谷氨酸能代谢物的浓度，以检查是否在双相后代和躁狂发作之前出现前额谷氨酸浓度的降低。 方法：918岁的儿童和青少年，有双相I型或II型障碍的家族风险（22名后代有确定的躁狂病史，“BD”，15名后代有亚综合征症状，但无躁狂，“SS”），和17名健康对照（“HC”）在3 T下使用质子磁共振波谱（1H-MRS）检查，以研究8 cc（2 x 2 x 2 cm）前扣带皮层（ACC）体素。 使用LCModel（Provencher，2001）处理数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: We aimed to compare concentrations of glutamatergic metabolites in bipolar offspring and healthy controls to examine whether decreases in prefrontal glutamate concentrations occur in bipolar offspringand prior to the onset of mania. Methods: 918 year old children and adolescents with a familial risk for bipolar I or II disorder (22 offspring with established history of mania,"BD," and 15 with subsyndromal symptoms without mania, "SS"), and 17 healthy controls ("HC") were examined using proton magnetic resonance spectroscopy (1H-MRS) at 3T to study glutamatergic concentrations in an 8 cc (2 x 2 x 2 cm) anterior cingulate cortex (ACC) voxel. Data was processed using LCModel (Provencher, 2001).