MECHANISMS OF BIOORGANIC AND ORGANOMETALLIC CYCLIZATION REACTIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本文提出的研究重点，CHE 030089 N的更新，是应用现代量子化学方法来阐明用于多环有机分子的合成和生物合成的有机化学反应的分子机制。在此授予期间，我们将专注于图1所示的三个子项目：（项目1;从上一个资助期继续）萜烯天然产物生物合成中涉及的阳离子促进的多环化反应，（项目2;从上一个资助期的相关项目扩展而来）用于合成复杂环状分子的周环反应，以及（项目3;从上一个赠款期延续）过渡金属促进σ迁移重排。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of the research proposed herein, a renewal of CHE030089N, is to apply modern quantum chemical methods to the elucidation of molecular mechanisms of organic chemical reactions that are used in the synthesis and biosynthesis of polycyclic organic molecules. During this award period, we will concentrate on the three subprojects shown in Figure 1: (project 1; continued from the previous grant period) cation-promoted polycyclization reactions involved in biosyntheses of terpene natural products, (project 2; expanded from the related project from the previous grant period) pericyclic reactions used in the synthesis of complex cyclic molecules, and (project 3; continued from the previous grant period) transition metal promoted sigmatropic rearrangements.