YOUNG ADULTS WITH ADDICTION: IMPULSIVITY, BRAIN DYSFUNCTION AND RECOVERY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将研究15名年轻人(18岁至25岁)，他们目前正在哈泽尔登联谊会接受可卡因或兴奋剂依赖的治疗(以及15名对照)。我们将研究神经生物学异常、神经认知和冲动，特别是当它们与恢复过程相关时。具体地说，受试者将在两个时间点接受神经认知测试和测量冲动的任务：在他们逗留的开始和大约60天时，通过积极的治疗和禁欲过程评估大脑恢复情况。既要完成冲动的自我评级(Barratt冲动程度)，也要完成衡量执行功能的计算机任务。出于类似的原因，脑成像扫描也将在这两个时间点完成。 这项研究的大脑成像部分将包括核磁共振扫描和GABA光谱，这将在加入团契俱乐部后不久和三个月内进行。虽然参与者基本上会充当自己的对照组，但我们也会招募年龄、性别、社会经济地位相匹配的健康对照组，因此可以将这些测试与正常对照组进行比较。同样的测量和扫描可以在对照组进行，包括在三个月后重复扫描，以测量GABA的正常变化。 该项目的目标是检查患有可卡因或苯丙胺依赖的年轻人(正在接受治疗)是否比对照组更冲动，并通过功能磁共振成像和GABA光谱分析确定滥用可卡因或苯丙胺的人存在的潜在大脑异常。根据脑部扫描的结果，我们希望确定这些上瘾的受试者在2个月的康复环境中是否发生了大脑恢复(例如，异常情况的改善)。通过神经认知测试，我们希望确定这些冲动的神经认知和行为指标是否与改变的GABA水平相关。最后，研究人员将检查在行为测量或功能磁共振上观察到的任何变化是否与康复结果有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will study 15 young adults (ages 18 to 25) who are currently in treatment for cocaine or stimulant dependence at Hazelden Fellowship Club (as well as 15 controls). We will study neurobiological abnormalities, neurocognition and impulsivity particularly as they are associated with the recovery process. Specifically, subjects will undergo neurocognitive testing and tasks measuring impulsivity at two time points: at the beginning of their stay and at approximately 60 days to assess brain recovery through the active process of treatment and abstinence. Both self-rating scales of impulsivity (Barratt Impulsivity Scale) and computer tasks measuring executive functioning will be done. Brain imaging scans would also be completed at these two time points for similar reasons. The brain imaging portion of the study will consist of MRI scans and GABA spectroscopy which will be conducted soon after admission to Fellowship club and at three months. Although the participants would essentially act as their own controls we also would recruit healthy controls matched on age, gender, socioeconomic status and thus would allow comparisons on these tests with normal controls. The same measures and scanning could be done with controls including a repeat scan at three months to measure normal variation in GABA. The goal of this project is to examine whether youth with cocaine or amphetamine dependence (who are in treatment) are more impulsive than controls, as well as to determine the underlying brain abnormalities that exist in people with cocaine or amphetamine abuse as measured by fMRI and GABA spectroscopy. Based on the results of the brain scans, we hope to determine whether brain recovery (e.g. amelioration of abnormalities) occurs in these subjects with addiction over a 2-month period of being in a recovery setting. Through the neurocognitive testing, we hope to determine whether these neurocognitive and behavioral measures of impulsivity are correlated with altered GABA levels. Finally, the researcher will examine if any of the changes observed on behavioral measures or the fMRI are associated with recovery outcomes.