PATHOPHYSIOLOGY OF ATM & P53

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 杨博士研究生长因子的信号转导和蛋白质翻译启动的机制。他的研究重点是两种重要的蛋白质，ATM和P53，这两种蛋白质对细胞周期进展、DNA损伤修复、神经元退化和胰岛素抵抗等多个生理过程至关重要。他的目标是了解ATM激酶如何在不同类型的细胞中发挥作用，以应对生长因子和细胞毒性压力。他还研究了如何在DNA损伤信号的作用下调控抑癌基因P53的翻译。杨博士将与奥格拉拉·拉科塔学院的桑多瓦尔博士合作开展一项研究，探讨这种植物提取物对糖尿病大鼠的影响。为这一合作购买动物和用品的工作正在进行中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Yang studies signal transduction of growth factors and the mechanism of protein translation initiation. His research focuses on two important proteins, ATM and p53, which are critical for multiple physiological processes such as cell cycle progress, DNA damage repair, neuronal degeneration, and insulin resistance. His goal is to understand how ATM kinase functions in various types of cells in response to growth factors and cytotoxic stresses. He also examines how translation of p53 tumor suppressor is regulated in response to DNA damage signals Dr. Yang will be carrying out a collaborative study with Dr. Sandoval from Oglala Lakota College on the effects of the plant extract on diabetic rats. The purchase of animals and supplies for this collaboration is in process.