Virology

VC的目标是通过提供最先进的BSL-2-3来支持、扩大和加强艾滋病毒/艾滋病研究 实验室设施和设备，经验丰富和敬业的专业工作人员，教育，培训，病毒学专业 研究材料、分析和蛋白质表达能力，所有这些都是为了支持多学科、由研究人员发起的 基础和临床艾滋病毒/艾滋病研究。我们的每一个具体目标都代表着艾滋病毒/艾滋病的显著增值 研究和整个CFAR任务，因为它们(I)使所有UAB调查人员能够进行现场艾滋病毒研究，(Ii)促进 由新的研究人员开展艾滋病毒/艾滋病研究，(3)扩大CFAR教职员工的研究能力， 以及(Iv)鼓励翻译性和多学科性质的研究。风险投资的服务是 艾滋病中心，因为他们为许多多学科的基础和临床艾滋病毒/艾滋病研究提供关键支持 程序。风险投资的具体目标如下： 1.提供和维护最先进的BSL 2-3实验室设施，以进行 “活”的艾滋病毒研究。 2.为在香港工作的所有教职员工提供安全教育和培训，并持续监督 BSL 2-3实验室。 3.通过咨询、针对化验的培训和提供 标准化的化验和确定的分子和病毒学试剂。 4.开发专门的基因工程工具和分析，包括细胞系和病毒载体， 帮助应对艾滋病毒/艾滋病研究中新的和重要的调查挑战。 5.继续为CFAR调查人员提供分子生物学服务、试剂和培训， 允许从基因克隆到基因结构和/或功能研究的快速进展 产品。 这一续签申请反映了学术艾滋病毒/艾滋病环境中发生的重要变化 自从这笔赠款上次竞争性续期以来，在全国和UAB都是如此。两个核心的关键服务 以前独立运行的中央病毒培养核心和分子生物学核心，已经 合并成单个核心，现在称为病毒学核心(VC)。此策略基于以下方面的相似性 前两个核心提供的病毒学服务的性质，旨在确保我们能够保留和 继续提供关键增值服务，同时最大限度地熟练利用宝贵的CFAR资源。

The goals of the VC are to enable, broaden and enhance HIV/AIDS research by providing state-of-the-art BSL-2-3 laboratory facilities and equipment, experienced and dedicated professional staff, education, training, virology-specific research materials and assays and protein expression capabilities, all to support multidisciplinary, investigator-initiated basic and clinical HIV/AIDS research. Each of our specific aims represent significant value-added to HIV/AIDS research and the overall CFAR mission as they (i) enable live HIV research among all UAB investigators, (ii) foster the development of HIV/AIDS research by new investigators, (iii) broaden the research capabilities among CFAR faculty, and (iv) encourage research that is translational and multidisciplinary in nature. The services of VC are integral to the AIDS Center as they provide critical support to numerous multidisciplinary basic and clinical HIV/AIDS research programs. The specific aims for the VC are as follows: 1. To provide and maintain state-of-the-art BSL 2-3 laboratory facilities that are necessary to conduct "live" HIV research. 2. To provide safety education and training, and ongoing supervision for all faculty and staff that work in the BSL 2-3 Laboratory. 3. To augment AIDS research capabilities through consultation, assay-specific training, and provision of standardized assays and defined molecular and virologic reagents. 4. To develop specialized genetically engineered tools and assays, including cell lines and viral vectors, to help address new and important investigative challenges in HIV/AIDS research. 5. To continue to offer CFAR investigators the molecular biology services, reagents, and training, that allow a rapid progression from cloning of genes to structure and/or function studies of the gene product. This renewal application reflects important changes that have occurred in the academic HIV/AIDS environment nationally and at UAB since this grant was last competitively renewed. The critical services of two cores that were previously operated independently, the Central Virus Culture Core and the Molecular Biology Core, have been combined into a single core that is now referred to as the Virology Core (VC). This strategy is based on similarities in the nature of virology services offered by the two previous cores and is meant to ensure that we are able to retain and continue to provide critical value-added services, while maximizing proficient utilization of precious CFAR resources.