CORE--CENTRAL VIRUS CULTURE

核心--中心病毒培养

• 批准号: 6268006
• 负责人: JOHN Christopher KAPPES
• 金额: $ 13.86万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6268006
• 关键词: AIDS; biohazard control; biomedical equipment resource; biomedical facility; human immunodeficiency virus; microorganism culture; training

The UAB CFAR has operated a Central Virus Core (CVC) shared resource since 1988. The specific aims of this core are: (1) To provide specially- designed and centrally-located BSL 2-3 laboratory space to all UAB investigators so that infectious HIV research can by physically restricted to specified areas; (2) To provide and maintain the high cost equipment needed for basic HIV research within the core facility in order to facilitate and broaden the research capabilities of all investigators and to avoid redundancy in equipment purchases; (3) To provide ongoing training, supervision, and monitoring of investigators and their research staff regarding BSL 2-3 practices required for HIV research with the CVC; (4) To foster the development of HIV/AIDS research by new and established investigators by providing a CVC staff with broad experience in basic and clinical HIV research which is dedicated to these goals. The CVC consists of two centrally-located biosafety level 2-3 (BSL 2-3) laboratories and their associated professional and technical staff. These laboratories are centrally located on the UAB campus in the vicinity of the greatest concentrations of HIV researchers. Together, they constitute 2500 square feet of BSL 2-3 laboratory space including nine self-contained 100 square foot tissue culture suites. Both the individual culture suites and the outer common equipment areas are completely equipped for molecular, biological, and clinical HIV research. The core is operated under the specific usages and priority guidelines established by the Core's Advisory Committee and complies with NIH/CDC recommendations for safe operating procedures. Since funded in 1988, the research of 45 principal investigators with federally funded grants have been accommodated in these facilities. Currently, the CVC supports the research of 24 UAB faculty representing 11 different departments and divisions within the School of Medicine. The CVC has trained, supervised, and assisted 105 researchers including graduated students, postdoctoral fellows, technicians, and faculty. Currently, there are a total of 64 active CVC users. In addition to R01-type projects, the CVC has supporter the research of major NIH funded program projects and contracts awarded to UAB investigators since 1988, including NCDDG, NCVDG, PEBRA, ACTG, AVEU, NICHD and HIV Genetic Variation projects. Over 300 peer-reviewed scientific publications have results from work performed within the CVC since 1993. Funding is requested to support the basic infrastructure costs of the CVC that remain despite a substantial chargeback system.

UAB CFAR经营中央病毒核心（CVC）共享资源，因为 1988年。该核心的具体目的是：（1）特别提供 - 为所有UAB设计和集中的BSL 2-3实验室空间 调查人员，以使感染性艾滋病毒研究可以通过身体受到限制 到指定区域； （2）提供和维护高成本设备 需要在核心设施中进行基本艾滋病毒研究 促进和扩大所有研究人员和 为了避免购买设备的冗余； （3）提供持续的 培训，监督和监测调查员及其研究 有关CVC艾滋病毒研究所需的BSL 2-3个实践的工作人员； （4）促进新和既定的艾滋病毒/艾滋病研究的发展 通过为CVC员工提供广泛的基本和 致力于这些目标的临床艾滋病毒研究。 CVC组成 在两个集中的生物安全2-3（BSL 2-3）实验室中 他们相关的专业和技术人员。这些实验室是 位于最伟大的UAB校园的中心位置 艾滋病毒研究人员的浓度。他们在一起构成2500平方 BSL 2-3实验室空间的英尺，包括9个独立100平方 脚组织培养套房。个体文化套件和 外部公共设备区域完全配备了分子， 生物学和临床HIV研究。核心在 由核心咨询制定的特定用法和优先指南 委员会并符合NIH/CDC的安全操作建议 程序。自1988年资助以来，45个校长的研究 拥有联邦资助的调查人员已得到满足 设施。目前，CVC支持24位UAB教师的研究 代表学校内的11个不同部门和分裂 药品。 CVC已经培训，监督和协助105位研究人员 包括毕业生，博士后研究员，技术人员和 学院。当前，共有64个活跃的CVC用户。此外 对于R01型项目，CVC支持了主要NIH的研究 自从授予UAB调查人员的资助计划项目和合同 1988年，包括NCDDG，NCVDG，PEBRA，ACTG，AVEU，NICHD和HIV遗传 变异项目。超过300多个同行评审的科学出版物已有 自1993年以来在CVC中执行的工作结果。资金是 要求支持CVC的基本基础设施成本 尽管有实质性的退款系统。