CORE--CENTRAL VIRUS CORE

UAB CFAR已运行中央病毒核心（CVC）共享资源 于1988年 该核心的具体目标是： 专门设计的位于中心的BSL-2/3实验室空间， 研究人员，使感染性艾滋病毒的研究可以在物理上 （二）提供所需的高成本设备; 艾滋病毒基础研究的核心基金， 为了促进和扩大所有人的研究能力， ㈢为调查人员提供必要的培训，避免设备采购的重复; 对研究者进行持续培训、监督和监测 及其研究人员关于艾滋病毒所需的BLS-2/3实践的信息 ㈣通过新的研究，促进艾滋病毒/艾滋病研究的发展; 研究人员，并鼓励新的多学科研究， 通过提供具有广泛经验的核心工作人员， 致力于这些目标的基础和临床艾滋病毒研究。 CVC由两个位于中心的生物安全2/3级（BSL-2/3） 实验室及其相关专业技术人员。 这些实验室位于UAB校园的中心， 艾滋病研究人员最集中的地方。 在一起， 他们构成了2500平方英尺的BSL-2/3空间，包括9个自我， 有100平方英尺的组织培养室 个体 文化套房和其他共同的设备领域是完全 为分子、生物和临床HIV研究提供设备。 核心 是根据既定的特定用途和优先级准则进行操作的 由核心咨询委员会和符合NIH/CDC 安全操作程序的建议。 在目前的五年中， 在一年的资助期内，CVC支持联邦资助的研究 32 UAB教师代表10个不同部门的项目， 医学院内的部门。 CVC已经训练好了， 指导和协助85名研究人员，包括研究生， 博士后研究员、技术人员和教员。 除了R 01型 CVC支持了NIH资助的五个主要项目的研究， 1988年至1999年期间授予UAB调查人员的计划项目和合同 和1993年，包括NCDDG、NCVDG、PEBRA、ACTG和HIV遗传变异 项目 已经产生了100多份同行评审的科学出版物 在CVC内进行的工作。 要求提供资金，以支持 CVC的基本运营成本仍然存在，尽管大量的 Chargeback系统已经到位。

The UAB CFAR has operated a Central Virus Core (CVC) shared resources since 1988. The specific aims of this core are: (i) To provide specially-designed, centrally-located BSL-2/3 laboratory space to all UAB investigators so that infectious HIV research can be physically restricted to specific areas; (ii) To provide high cost equipment needed for basic HIV research on a shared basis within the core facility in order to facilitate and broaden the research capabilities of all investigators and to avoid redundancy in equipment purchases; (iii) To provide ongoing training, supervision, and monitoring of investigators and their research staff regarding BLS-2/3 practices required for HIV research; (iv) To foster the development of HIV/AIDS research by new investigators and to encourage multidisciplinary research by new and established investigators by providing a core staff with broad experience in basic and clinical HIV research which is dedicated to these goals. The CVC consists of two centrally-located biosafety level 2/3 (BSL-2/3) laboratories and their associated professional and technical staff. These laboratories are centrally located on the UAB campus in the vicinity of the greatest concentrations of HIV researchers. Together, they constitute 2500 square feet of BSL-2/3 space including nine self- contained 100 square foot tissue culture suites. Both the individual culture suites and the other common equipment areas are completely equipped for molecular, biological, and clinical HIV research. The core is operated under the specific usage and priority guidelines established by the core's advisory committee and in compliance with NIH/CDC recommendations for safe operating procedures. During the current five year funding period, the CVC has supported federally-funded research projects of 32 UAB faculty representing 10 different departments and divisions within the School of Medicine. The CVC has trained, supervised, and assisted 85 researchers including graduate students, postdoctoral fellows, technicians, and faculty. In addition to R01-type projects, the CVC has supported research for five major NIH funded program projects and contracts awarded to UAB investigators between 1988 and 1993, including NCDDG, NCVDG, PEBRA, ACTG, and HIV Genetic Variation projects. Over 100 peer-reviewed scientific publications have resulted from work performed within the CVC. Funding is requested to support the basic operational costs of the CVC that remain despite a substantial chargeback system already in place.