BACTERIAL ANTIBIOTIC RESISTANCE IN AGRICULTURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肠沙门氏菌是一种具有重要临床意义的兼性厌氧菌，属于革兰氏阴性菌属肠杆菌科。最近，美国爆发了沙门氏菌病。新墨西哥州和得克萨斯州的沙门氏菌病发病率比其他大多数州都要高。为了重建临床疗效，重要的是要确定特定的抗菌剂对与暴发有关的肠球菌的有效程度。因此，我们将验证NM临床分离的肠球菌对临床相关抗菌药敏感的假设。这种抗菌素敏感性数据对于最终绕过耐药性决定因素和建立防止滋生抗菌素耐药性机制出现的条件的做法是必要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The bacterium Salmonella enterica is a clinically-important facultatively anaerobic rod and a member of the Enterobacteriaceae family of Gram-negative bacteria. Recently, an outbreak of salmonellosis occurred in the United States. New Mexico and Texas had relatively higher incidence rates of salmonellosis than most other states. In order to reestablish clinical efficacy, it would be important to determine the extent to which specific antimicrobial agents are effective against S. enterica which are implicated in outbreaks. Hence, we will test the hypothesis that the NM clinical isolates of S. enterica are susceptible to clinically-relevant antimicrobial agents. Such antimicrobial susceptibility data is necessary for ultimately circumventing resistance determinants and in establishing practices which prevent conditions that foster emergence of antimicrobial resistance mechanisms.