Center for the Biologic Basis of Oral/Systemic Disease (CBBOSD)

描述（由申请人提供）：自20世纪初以来，慢性口腔感染与一般健康之间的联系已被认识到。在过去的20年里，回顾性流行病学研究、前瞻性纵向研究以及干预研究都支持这些慢性口腔感染伴随慢性炎症与各种全身性疾病及其后遗症相关。口腔/系统疾病生物学基础中心（CBBO/SD）的延续申请涉及国家牙科和颅面研究所（NIDCR）关于改善美国人口口腔和一般健康的主要倡议。CBBO/SD分为3个临床项目：项目1：口腔和宫颈/阴道黏膜慢性炎症；项目二：颞下颌疾患及纤维肌痛患者应激反应的生理学研究；项目3：炎症性肠病患者的口腔-肠道协同免疫反应；2个转化科学项目：项目4：粘膜表面先天免疫反应的个体发生；项目5：口面部疼痛的基因治疗。这些项目招募了来自英国牙科学院、护理学院和医学院的初级研究人员，以及来自英国多所学院的高级导师/共同研究人员。项目的主题界面侧重于慢性炎症对口腔和全身疾病的贡献。研究对象包括孕妇、慢性口面部疼痛患者和炎症性肠病患者。这些临床项目在对先天免疫反应和炎症的共同理解水平上与转化项目相互作用，并为慢性口面部疼痛提供新的治疗干预策略。CBBO/SD通过提供赠款管理支持、教育机会、生物统计学/生物信息学核心和临床研究中心，为初级教师的发展提供基础设施。CBBO/SD的延续得益于中心在最初任期内成功地将初级研究人员转变为独立资助，加上大学和各个学院的大量投资。

DESCRIPTION (provided by applicant): The link between chronic oral infections and general health has been recognized since the early 20th century. During the last 2 decades, retrospective epidemiological studies and prospective longitudinal, as well as intervention, studies have supported that these chronic oral infections with accompanying chronic inflammation associate with various systemic diseases and their sequelae. This continuation application for the Center for the Biologic Basis of Oral/System Diseases (CBBO/SD) addresses major initiatives of the National Institute of Dental and Craniofacial Research (NIDCR) regarding improving oral and general health ofthe U.S. population. The CBBO/SD is organized into 3 cInical projects: Project 1: Chronic Inflammation at the Oral and Cervico/Vaginal Mucosa; Project 2: Physiology of the Stress Response in Patients with Temporomandibular Disorders and Fibromyalgia; Project 3: Coordinated Oral-Intestinal Immune Response in Patients with Inflammatory Bowel Diseases; and 2 translational science projects: Project 4: Ontogeny of Innate Immune Responses at Mucosal Surfaces; and Project 5: Gene Therapy for Orofacial Pain. These projects enlist junior investigators from the Colleges of Dentistry, Nursing, and Medicine, as well as senior mentors/co-investigators from multiple colleges at UK. The thematic interface of the projects focuses on the contribution of chronic inflammation to oral and systemic diseases. They engage populations of expectant women, patients with chronic orofacial pain, and inflammatory bowel disease. These clinical projects interact with the translational projects at the level of a common understanding of innate immune responses and inflammation, and novel therapeutic intervention strategies forthe chronic orofacial pain. The CBBO/SD provides an infrastructure for development of the junior faculty by providing grants management support, educational opportunities, a biostatistics/bioinformatics core, and a clinical research center. The continuation of the CBBO/SD is supported by the success during the initial tenure of the center in transitioning junior investigators towards independent funding, coupled with substantial investment from the university and individual colleges.