PREVENTION OF ACTIVE TUBERCULOSIS BY INFECTION WITH H PYLORI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们推测，幽门螺杆菌可能非特异性地增强宿主的免疫反应，并帮助维持结核分枝杆菌的潜伏状态。我们建议用两个特定的目标来检验这一新的假设，这两个目标是利用正在进行的关于人类和非人类灵长类动物中结核病潜伏期的研究。如果成功，后续的提案将开发一种干预措施，操纵自然微生物区系来模拟这种保护性免疫反应，首先是在非人类灵长类动物中，然后是在人类的第一阶段临床试验中。该项目的具体目的是确定感染结核分枝杆菌的食蟹猴的潜伏期与幽门螺杆菌感染率之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that H. pylori may non-specifically boost the host immune response and help maintain M. tuberculosis in a latent state. We propose to test this novel hypothesis with two specific aims that exploit ongoing studies of tuberculosis latency in humans and in non-human primates. If successful, a subsequent proposal will develop an intervention that will manipulate the natural microbiota to mimic this protective immune response, first in non-human primates and then in a Phase 1 clinical trial in humans. The specific aim of this project is to determine the relationship between latency and the prevalence of H. pylori among cynomolgus monkeys challenged with M. tuberculosis.