课题基金 / 基金详情

Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens

Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
HIV-1 免疫原引发的中和抗体的临床前评估
批准号：
7964805
负责人：
John Mascola
金额：
$21.17万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7964805
关键词：
AdenovirusesAnimalsAntibodiesAntibody FormationAntigensDNAGlycoproteinsHIV-1ImmunizationMacaca mulattaProteinsRecombinantsStructureTreatment ProtocolsVaccinesbaseneutralizing antibodynovelplasmid DNApreclinical evaluation

项目摘要

项目成果

John Mascola的其他基金

相似基金

相关文献

中文摘要
翻译
本研究考察了小动物和恒河猴在不同免疫方案后中和抗体反应的广度和幅度。使用标准化的多层参考Env假病毒面板进行中和抗体评估，我们发现蛋白质免疫和DNA引物（rAd增强免疫）都可以产生高抗体滴度。正在进行的研究是基于基于结构的信息从HIV-1包膜糖蛋白的研究评估新的免疫原。
英文摘要
The present studies examine the breadth and magnitude of neutralizing antibody responses in small animals and rhesus monkeys after various immunization regimens. Using a standardized multi-tier panel of reference Env pseudoviruses for neutralizing antibody assessment, we show that both protein immunization, and DNA prime, rAd boost immunization, can generate high antibody titers. Ongoing studies are evaluating novel immunogens based on structure-based inforamiton from studies of the HIV-1 envelope glycoprotein.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention
HIV/AIDS Vaccine and Antibody Development
Pre-clinical Vaccine Development for Respiratory Viruses
Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)
海外基金