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Epigenetic Regulation of Adipogenesis

Epigenetic Regulation of Adipogenesis
脂肪生成的表观遗传调控
批准号：
7967813
负责人：
Kai Ge
金额：
$26.23万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7967813
关键词：
AccountingAcetylationBiological AssayDiabetes MellitusDiseaseEnzymesEpigenetic ProcessFunctional RNAGene ActivationGene ExpressionGene Expression RegulationHistone AcetylationHistone H3HistonesLipodystrophyLysineMethylationMethyltransferaseMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusObesityPPAR gammaPhasePlayRegulationRepressionRisk FactorsRoleSitechromatin remodelinghistone modificationlipid biosynthesismortalitypromoter

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中文摘要
翻译
特异性目的1：研究PPARgamma启动子组蛋白修饰在脂肪形成早期的变化。通过ChIP实验，我们观察到在脂肪形成的早期，PPARgamma启动子上的多个组蛋白乙酰化和甲基化发生了强烈的变化。
英文摘要
Specific Aim 1: examine the change of histone modifications on PPARgamma promoter in the early phase of adipogenesis. By ChIP assays, we have observed robust change of multiple histone acetylation and methylation on PPARgamma promoter in the early phase of adipogenesis. Specific Aim 2: investigate the functional significance of the histone modification change on PPARgamma promoter by depleting the responsible enzymes. Specific Aim 3: investigate the roles of other epigenetic mechanisms, in particular chromatin remodeling and non-coding RNAs, in regulation of PPARgamma expression and adipogenesis.
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会议论文
Epigenetic Regulation of Nuclear Receptor Target Gene Expression
Epigenetic Regulation of Adipogenesis
Regulation of PPARgamma and Adipogenesis by MLL3/MLL4 complex
Regulation of PPARgamma and Adipogenesis by Mediator and MED1/TRAP220
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