Statistical Methods for Mendelian Randomization

这是一个新启动的研究项目。 在传统的流行病学研究中，表型（危险因素）和疾病之间的联系往往受到混杂和反向因果关系的影响。由于一个人的基因型是由一个看似随机的过程分配的，基因是潜在的有用的工具变量，用于调整这种偏见。这种类型的调整结合了基因型-疾病关联和基因型-表型关联的信息，以估计表型-疾病关联，并被称为孟德尔随机化。 本计画旨在发展孟德尔随机化的各种有效统计方法，包括研究设计、模型化与估计。

This is a newly initiated research project. In traditional epidemiological studies the association between phenotype (risk factor) and disease is often biased by confounding and reverse causation. As a persons genotype is assigned by a seemingly random process, genes are potentially useful instrumental variables for adjusting for such bias. This type of adjustment combines information on the genotypeCdisease association and the genotypeCphenotype association to estimate the phenotypeCdisease association and has become known as Mendelian randomization. This project aims at developing various efficient statistical methods for Mendelian Randomiztion, ranging from study design, modeling and estimation.