A Structural & Functional Study of the Upper Airway in Adolescent Girls with PCOS

描述(申请人提供)：多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一，与超重和肥胖有关。它影响5%-10%的青春期女孩和育龄妇女。诊断需要以下三种症状中的两种：1)少或无排卵，2)雄激素过多的临床和/或生化体征，或3)多囊卵巢。考虑到大多数女性超重或肥胖，胰岛素抵抗是多囊卵巢综合征的一个主要特征。其他代谢紊乱，包括糖尿病和高脂血症也很常见。最近发现多囊卵巢综合征与阻塞性睡眠呼吸暂停综合征(OSAS)有关，后者可能进一步导致严重的心血管和神经认知缺陷。然而，缺乏关于导致患有多囊卵巢综合征的妇女或青春期女孩OSAS的机制的研究。这项建议的首要目标是确定13-18岁患有多囊卵巢综合征的女孩OSAS的解剖和功能危险因素。我们将使用最先进的图像采集、处理和分析技术来开发上呼吸道和周围组织的功能模型。这样的模型将预测OSAS的严重程度，并使治疗策略的制定成为可能。我们预计，这项研究中开发的工具将应用于儿童和成人的其他OSAS表型。(摘要结束)

DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders associated with overweight and obesity. It affects 5-10% of adolescent girls and women of reproductive age. Diagnosis requires two of the following three symptoms 1) oligo- or anovulation, 2) clinical and/or biochemical signs of excess androgens, or 3) polycystic ovaries. Insulin resistance is a cardinal feature of PCOS given that the majority of women are overweight or obese. Other metabolic derangements including diabetes and hyperlipidemia are also common. PCOS has recently been shown to be associated with obstructive sleep apnea syndrome (OSAS) that may further lead to significant cardiovascular and neurocognitive deficits. However, studies of the mechanisms leading to OSAS in women or adolescent girls with PCOS are lacking. The overarching goal of this proposal is to determine the anatomical and functional risk factors for OSAS in girls with PCOS aged 13-18 years. We will use state-of-the-art techniques for image acquisition, processing and analysis to develop a functional model of the upper airway and surrounding tissues. Such a model will predict the severity of OSAS and enable the development of treatment strategies. We foresee that tools developed in this study will be applied to other phenotypes of OSAS in both children and adults. (End of Abstract)