Brain Cancer Xenotransplant Model for Drug Screening

描述（由申请人提供）：在这项研究中，我们将开发斑马鱼作为一种新的异种移植动物模型，以评估脑癌进展并确定潜在的候选药物。脑癌约占成人癌症的10 - 30%，许多形式的癌症可以转移到大脑。尽管免疫缺陷小鼠和大鼠作为脑癌异种移植物的宿主发挥了重要作用，但需要一种简单且具有成本效益的原位脑癌模型来进行更有效的体内癌症药物筛选。 公共卫生相关性：在这项研究中，我们建议开发斑马鱼作为一种新的异种移植动物模型，以评估脑癌进展，识别潜在的候选药物，并对疗效进行排名。

DESCRIPTION (provided by applicant): In this research, we will develop zebrafish as a new xenotransplant animal model to assess brain cancer progression and identify potential drug candidates. Brain cancer accounts for approximately 10 - 30% of adult cancers and many forms of cancer can metastasize to the brain. Although immunodeficient mice and rats have played an important role as hosts for brain cancer xenografts, a simple and cost-effective orthotopic brain cancer model is required for more efficient in vivo cancer drug screening. PUBLIC HEALTH RELEVANCE: In this research, we propose to develop zebrafish as a new xenotransplant animal model to assess brain cancer progression, identify potential drug candidates, and rank efficacy.