Acquisition of a 400MHz Solution NMR System with an Autosampler

描述（由申请人提供）：田纳西大学健康科学中心正在申请资金购买一台新的400 MHz NMR光谱仪，该光谱仪将取代我们已有17年历史的Bruker ARX-300 MHz NMR。连同一个装备精良的500 MHz仪器，用于先进的NMR实验，该仪器将在校园的共享NMR设施内管理。该仪器将支持许多正在进行的NIH资助的研究项目，这些项目主要集中在小分子药物发现和药物递送方面。300 MHz NMR已用于步行模式下的常规NMR研究。所要求的新的，简单的双通道解决方案400 MHz NMR需要取代老化和技术上有限的300 NMR。它将配备一个基本的样品交换器和一个宽带探头，自动调谐到药物化学中通常遇到的核（1H，19 F，13 C，31 P和15 N）。它提供了显着更高的灵敏度，更高的吞吐量，并大大提高了性能相比，旧的300核磁共振，它取代。它还将为药物化学家提供自动化，常规二维NMR测量的能力，从而在500 MHz NMR上释放宝贵的仪器时间，这是许多正在进行和扩展的NIH支持项目的高级实验所需的。主动屏蔽磁体大大减少了杂散磁场，使我们能够更好地利用宝贵的实验室空间。通过NIH资助的研究发现的几种候选药物已经获得许可，并正在商业化过程中。新的400 MHz的收购将大大加强NIH资助的生物医学研究和研究生的培训。田纳西大学健康科学中心坚定地致力于支持生物医学研究，这两个目前的核磁共振仪器都是用大学的资金购买和维护的。

DESCRIPTION (provided by applicant): The University of Tennessee Health Science Center is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our 17-year old Bruker ARX-300 MHz NMR. Together with a well equipped 500 MHz instrument for advanced NMR experiments, this instrument will be managed within the campus's Shared NMR Facility. This instrument will support many on-going, NIH funded research projects that mainly focus on small molecular drug discovery and drug delivery. The 300 MHz NMR has been used for routine NMR studies in a walk-up mode. The requested new, simple two-channel solution 400 MHz NMR is needed to replace the aging and technically limited 300 NMR. It will be equipped with a basic sample changer and one broadband probe that automatically tune to nuclei usually encountered in medicinal chemistry (1H, 19F, 13C, 31P and 15N). It offers significantly greater sensitivity, higher throughput, and substantially better performance compared with the old 300 NMR that it replaces. It will also provide capability for automated, routine two dimensional NMR measurements for medicinal chemists, freeing up valuable instrument time on the 500 MHz NMR which is needed for many advanced experiments for on-going and expanded NIH supported projects. The actively shielded magnet has greatly reduced stray field which will allow us to make better use of valuable lab space. Several drug candidates discovered through NIH funded research on this campus have been licensed and are in the commercialization process. The acquisition of the new 400 MHz will enhance NIH funded biomedical research and the training of graduate students substantially. The University of Tennessee Health Science Center has strong commitment to support biomedical research, as evidenced by the fact that both current NMR instruments were purchased and well maintained with funds from the university.